Safety of altrenogest in pregnant mares and on health and development of offspring
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Cited by (22)
Hormone supplementation protocol using estradiol benzoate and long-acting progesterone is efficient in maintaining pregnancy of anovulatory recipient mares during autumn transitional phase
2015, Animal Reproduction ScienceCitation Excerpt :In addition, ovariectomized mare recipients are able to establish and maintain pregnancy when treated with progesterone until Day 100 of gestation (Hinrichs et al., 1987). For these reasons, hormonal protocols using progestins (Hinrichs et al., 1986; McKinnon et al., 1988; Shoemaker et al., 1989), progesterone (Hinrichs et al., 1987; Vanderwall et al., 2007), estradiol benzoate plus either progestins (Wiepz et al., 1988) or progesterone (Kaercher et al., 2013) have been used successfully to maintain pregnancy in anovulatory and ovariectomized embryo recipient mares. Thus, hormonal administration to anovulatory mares can make them suitable as embryo recipients, thereby reducing the problems associated to donor/recipient estrous synchronization and allowing the use of more recipients at the end of breeding season (Silva et al., 2014).
Laparoscopic Gonadectomy in Two Intersex Warmblood Horses
2012, Journal of Equine Veterinary ScienceCitation Excerpt :Other reasons for stallion-like behavior are treatment with androgens or neoplasia of the ovaries such as granulosa cell tumor [35,36]. In case of foals of mares treated with altrenogest in late pregnancy, an enlarged clitoris has been described [37]. However, there was no history available concerning treatments of the two horses’ dams during pregnancy.
Concentrations of altrenogest in plasma of mares and foals and in allantoic and amniotic fluid at parturition
2010, TheriogenologyCitation Excerpt :This is similar to results from previous studies on cortisol metabolism in mature, healthy foals, showing high plasma cortisol concentrations within the first hour of life and a rapid decline within less than 8 h thereafter [28,29]. A lack of detrimental effects on foals from altrenogest-treated mares where administration was ceased at day 320, i.e., several days before parturition occurred [19] does not only show that the fetus is capable of clearing altrenogest from tissues but also suggests that effects are caused by acute action of altrenogest on respective tissue. In contrast to foals, negative effects have never been reported in mares treated with altrenogest [17–19,30,31].
Effects of progesterone administration to mares during late gestation
2002, TheriogenologyProgestins in Mid- to Late-Pregnant Mares
1994, Journal of Equine Veterinary ScienceUse of progestins in open and pregnant mares
1993, Animal Reproduction Science
Authors' address: Animal Reproduction Laboratory, Colorado State University, Fort Collins, CO 80523.