Journal of Equine Veterinary Science
Volume 32, Issue 2 , Pages 75-79 , February 2012

The Effect of Season on the Histologic and Histomorphometric Appearance of the Equine Pituitary Gland

  • Melissa Cordero, DVM

      Affiliations

    • Department of Physiological Sciences, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK
    • ,
  • Dianne McFarlane, DVM, PhD

      Affiliations

    • Department of Physiological Sciences, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK
    • Corresponding Author InformationCorresponding author at: Dianne McFarlane, DVM, PhD, Department of Physiological Sciences, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74074.
    • ,
  • Melanie A. Breshears, DVM, PhD

      Affiliations

    • Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK
    • ,
  • Lisa M. Miller, DVM, PhD

      Affiliations

    • Department of Pathology and Microbiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada
    • ,
  • Margaret A. Miller, DVM, PhD

      Affiliations

    • Department of Comparative Pathobiology, School of Veterinary Medicine, Purdue University, West Lafayette, IN
    • ,
  • Wendy M. Duckett, DVM, MS

      Affiliations

    • Department of Health Management, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada

Received 26 July 2010 ,Revised 9 October 2010 ,Accepted 11 January 2011.

References 

  1. Schott HC. Pituitary pars intermedia dysfunction: equine Cushing’s disease. Vet Clin North Am. 2002;18:237–270
  2. Orth DN, Nicholson WE. Bioactive and immunoreactive adrenocorticotropin in normal equine pituitary and in pituitary tumors of horses with Cushing’s disease. Endocrinology. 1982;111:559–563
  3. Frank N, Andrews FM, Sommardahl CS, Eiler H, Rohrbach BW, Donnell RL. Evaluation of the combined dexamethasone suppression/thyrotropin-releasing hormone stimulation test for detection of pars intermedia pituitary adenomas in horses. J Vet Intern Med. 2006;20:987–993
  4. McFarlane D, Donaldson MT, McDonnell SM, Cribb AE. Effects of season and sample handling on measurement of plasma alpha-melanocyte-stimulating hormone concentrations in horses and ponies. Am J Vet Res. 2004;65:1463–1468
  5. Place NJ, McGowan CM, Lamb SV, Schanbacher BJ, McGowan T, Walsh DM. Seasonal variation in serum concentrations of selected metabolic hormones in horses. J Vet Intern Med. 2010;24:650–654
  6. Donaldson MT, McDonnell SM, Schanbacher BJ, Lamb SV, McFarlane D, Beech J. Variation in plasma adrenocorticotropic hormone concentration and dexamethasone suppression test results with season, age and sex in healthy ponies and horses. J Vet Intern Med. 2005;19:217–222
  7. Dybdal NO, Madigan JE, Kennedy PC. Diagnostic testing for pituitary pars intermedia dysfunction in horses. J Am Vet Med Assoc. 1994;204:627–632
  8. Miller MA, Pardo ID, Jackson LP, Moore GE, Sojka JE. Correlation of pituitary histomorphometry with adrenocorticotrophic hormone response to domperidone administration in the diagnosis of equine pituitary pars intermedia dysfunction. Vet Pathol. 2008;45:26–38
  9. McFarlane D, Miller LM, Craig LE, Dybdal NO, Habecker PL, Miller MA, et al. Agreement in histologic assessments of the pituitary pars intermedia in aged horses. Am J Vet Res. 2005;66:2055–2059
  10. van der Kolk JH, Heinrichs M, van Amerongen JD, Stooker RC, in de Wal LJ, van den Ingh TS. Evaluation of pituitary gland anatomy and histopathologic findings in clinically normal horses and horses and ponies with pituitary pars intermedia adenoma. Am J Vet Res. 2004;65:1701–1707
  11. Lebaili N, Bensalem M, Stoeckel ME. The pituitary intermediate lobe of the hydrated and dehydrated gerbil. An immunohistochemical and electron-microscopic study. Cells Tissues Organs. 1999;164:155–166
  12. Leatherland JF. Seasonal variation in the structure and ultrastructure of the pituitary gland in the marine form (trachurus) of the threespine stickleback gasterosteus aculeatus L: part II. Proximal pars distalis and neuro-intermediate lobe. Z Zellforsch Mikrosk Anat. 1970;104:318–336
  13. Acosta M, Mohamed F. Pituitary pars intermedia of male viscacha (lagostomus maximus maximus): a morphometric study of seasonal and age-related changes in immunohistochemistry. Cells Tissues Organs. 2009;190:219–229

PII: S0737-0806(11)00021-9

doi: 10.1016/j.jevs.2011.01.003

Journal of Equine Veterinary Science
Volume 32, Issue 2 , Pages 75-79 , February 2012

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