Journal of Equine Veterinary Science
Volume 30, Issue 5 , Pages 244-248 , May 2010

Stimulation of Ovulation in Seasonally Anovulatory and Vernal Transitional Mares with Estradiol and Domperidone: Dose and Combination Studies

  • Pamela B. Mitcham, MS

      Affiliations

    • School of Animal Sciences, Louisiana Agriculture Experiment Station, LSU Agricultural Center, Baton Rouge, LA
    • ,
  • Donald L. Thompson Jr., PhD

      Affiliations

    • School of Animal Sciences, Louisiana Agriculture Experiment Station, LSU Agricultural Center, Baton Rouge, LA
    • Corresponding Author InformationReprint requests: Donald L. Thompson, Jr., PhD, School of Animal Sciences, Louisiana State University, Baton Rouge, LA 70803-4210.
    • ,
  • Tad T. Thompson, DVM

      Affiliations

    • Equine Reproductive Center of Equine Services Hospital, Simpsonville, KY
    • ,
  • Scott D. Bennett, DVM

      Affiliations

    • Equine Reproductive Center of Equine Services Hospital, Simpsonville, KY
    • ,
  • Patrick J. Burns, PhD

      Affiliations

    • BioRelease Technologies, Lexington, KY
    • BET Pharm, Lexington, KY
    • ,
  • Thomas J. Caltabilota, MS

      Affiliations

    • School of Animal Sciences, Louisiana Agriculture Experiment Station, LSU Agricultural Center, Baton Rouge, LA

References 

  1. Brendemuehl JP, Cross DL. Influence of the dopamine antagonist domperidone on the vernal transition in seasonally anoestrous mares. J Reprod Fertil Suppl. 2000;56:185–193
  2. Besognet B, Hansen BS, Daels PF. Introduction of reproductive function in anestrous mares using a dopamine antagonist. Theriogenology. 1997;47:467–480
  3. Mari G, Morganti M, Merlo B, Castagnetti C, Parmeggiani F, Govoni N, et al. Administration of sulpiride or domperidone for advancing the first ovulation in deep anestrous mares. Theriogenology. 2009;71:959–965
  4. McCue PM, Buchanan B, Farquhar V, Squires EL, Cross EL. Efficacy of domperidone on induction of ovulation in anestrous and transitional mares. Proc Am Assoc Equine Pract. 1999;45:217–218
  5. Donadeu FX, Thompson DL. Administration of sulpiride to anovulatory mares in winter: effects on prolactin and gonadotropin concentrations, ovarian activity, ovulation and hair shedding. Theriogenology. 2002;57:963–976
  6. Kelley KK, Thompson DL, Storer WA, Mitcham PB, Gilley RM, Burns PJ. Estradiol interactions with dopamine antagonists in mares: prolactin secretion and reproductive traits. J Equine Vet Sci. 2006;26:517–528
  7. Thompson DL, Mitcham PB, Runles ML, Burns PJ, Gilley RM. Prolactin and gonadotropin responses in geldings to injections of estradiol benzoate in oil, estradiol benzoate in biodegradable microspheres, and estradiol cypionate. J Equine Vet Sci. 2008;28:232–237
  8. Henneke DR, Potter GD, Kreider JL, Yeates BF. Relationship between condition score, physical measurements and body fat percentage in mares. Equine Vet J. 1983;15:371–376
  9. Colborn DR, Thompson DL, Rahmanian MS, Roth TL. Plasma concentrations of cortisol, prolactin, luteinizing hormone, and follicle-stimulating hormone in stallions after physical exercise and injection of secretagogue before and after sulpiride treatment in winter. J Anim Sci. 1991;69:3724–3732
  10. Daels PF, Fatone S, Hansen BS, Concannon PW. Dopamine antagonist-induced reproductive function in anoestrous mares: gonadotropin secretion and effect of environmental cues. J Reprod Fertil Suppl. 2000;56:173–184
  11. Thompson DL, Hoffman R, DePew CL. Prolactin administration to seasonally anestrous mares: reproductive, metabolic, and hair shedding responses. J Anim Sci. 1997;75:1092–1099
  12. Woodley SL, Burns PJ, Douglas RH, Oxender WD. Prolonged interovulatory interval after oestradiol treatment in mares. J Reprod Fertil Suppl. 1979;27:205–209

 Approved for publication by the Director of the Louisiana Agric. Exp. Sta. as manuscript no. 2009-230-3703.

PII: S0737-0806(10)00169-3

doi: 10.1016/j.jevs.2010.03.007

Journal of Equine Veterinary Science
Volume 30, Issue 5 , Pages 244-248 , May 2010

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