Journal of Equine Veterinary Science
Volume 30, Issue 5 , Pages 231-236 , May 2010

In Vitro Evaluation of the Antibiotic Activity of Combinations of Ophthalmic Drugs Against Common Equine Ocular Pathogens

Presented in part at the 25th Annual Forum of the American College of Veterinary Internal Medicine, Seattle, WA 2007.

  • Imogen C. Johns, BVSc

      Affiliations

    • Department of Clinical Studies, University of Pennsylvania, Kennett Square, PA
    • Corresponding Author InformationReprint requests: Imogen C. Johns, BVSc, Department of Veterinary Clinical Sciences, Royal Veterinary College, University of London, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire, AL97TA, UK.
    • ,
  • Jill Beech, VMD

      Affiliations

    • Department of Clinical Studies, University of Pennsylvania, Kennett Square, PA
    • ,
  • Charles E. Benson, PhD

      Affiliations

    • Department of Pathobiology, University of Pennsylvania, Kennett Square, PA
    • ,
  • Louise L. Parente, BVSc, PhD

      Affiliations

    • Department of Clinical Studies, University of Pennsylvania, Kennett Square, PA

References 

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  2. Chmielewski N, Brooks DE, Smith PJ, Hendrix DV, Whittaker C, Gelatt KN. Visual outcome and ocular survival following iris prolapse in the horse: a review of 32 cases. Equine Vet J. 1997;29:31–39
  3. Moore CP, Collins BK, Fales WH, Halenda RM. Antimicrobial agents for treatment of infectious keratitis in horses. J Am Vet Med Assoc. 1995;207:855–862
  4. Hinkle KM, Gerding PA, Kakoma I, Schaeffer DJ. Evaluation of activity of selected ophthalmic antimicrobial agents in combination against common ocular microorganisms. Am J Vet Res. 1999;60:316–318
  5. Andrew SE, Willis AM. Diseases of the cornea and sclera. In:  Gilger BC editors. Equine ophthalmology. St. Louis, MO: Elsevier Saunders; 2005;p. 157–251
  6. Cutler TJ. Perfect Placement of Lavage Systems. In: Proceedings of the American College of Veterinary Internal Medicine Annual Forum; 2007.
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  8. Scotty NC, Brooks DE, Schuman CD. In vitro efficacy of an ophthalmic drug combination against corneal pathogens of horses. Am J Vet Res. 2008;69:101–107
  9. Giguère S. Antimicrobial drug action and interaction: an introduction. In:  Giguère S,  Prescott JF,  Baggott JS,  Walker RD,  Dowling PM editor. Antimicrobial therapy in veterinary medicine. 4th ed. Ames, IA: Blackwell Publishing; 2006;p. 3–9
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  11. Matthews AG. Ophthalmic antimicrobial therapy in the horse. Equine Vet Educ. 2009;21:271–280
  12. Keller RL, Hendrix DVH. Bacterial isolates and antimicrobial susceptibilities in equine bacterial ulcerative keratitis (1993-2004). Equine Vet J. 2005;37:207–211
  13. Giamarellou H. Aminoglycosides plus beta-lactams against gram-negative organisms. Evaluation of in vitro synergy and chemical interactions. Am J Med. 1986;80:126–137
  14. Bowe BE, Snyder JW, Eiferman RA. An in vitro study of the potency and stability of fortified antibiotic preparations. Am J Ophthalmol. 1991;111:686–689
  15. Phillips G, Johnson BE, Ferguson J. The loss of antibiotic activity of ciprofloxacin by photodegredation. J Antimicrob Chemother. 1990;26:783–789
  16. Earp CM, Barriere SL. The lack of inactivation of tobramycin by cefazolin, cefamandole and moxalactam in vitro. Drug Intell Clin Pharm. 1985;19:677–679
  17. Cappelletty DM, Rybak NJ. Comparison of methodologies for synergism testing of drug combinations against resistant strains of Pseudomonas aeruginosa. Antimicrob Agents Chemother. 1996;40:677–683
  18. Haffner JC, Fecteau KA, Eiler H. Inhibition of collagenase breakdown of equine corneas by tetanus anti-toxin, equine serum and acetylcysteine. Vet Ophthalmol. 2003;6:67–72
  19. Brooks DE, Ollivier FJ, Schultz GS, Andrew SE, Lassaline ME, Kallberg ME, et al. Duration of in vitro inhibitory activity of equine serum against tear film matrix metalloproteinases. In: Presented at the Association for Research in Vision and Ophthalmology Annual Meeting; 2003; Fort Lauderdale, FL. Abstract 902.
  20. Ben-Shlomo G, Plummer C, Barrie K, Brooks D. In vitro efficacy of an ophthalmic drug combination against corneal pathogens of horses. Abstract presented at the American College of Veterinary Ophthalmologists 39th Annual Meeting; 2008; Boston, MA.
  21. Berry M, Gurung A, Easty DL. Toxicity of antibiotics and antifungals on cultured human corneal cells: effect of mixing, exposure and concentration. Eye. 1995;9:110–115

PII: S0737-0806(10)00168-1

doi: 10.1016/j.jevs.2010.03.006

Journal of Equine Veterinary Science
Volume 30, Issue 5 , Pages 231-236 , May 2010

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