Journal of Equine Veterinary Science
Volume 30, Issue 3 , Pages 134-140 , March 2010

Antimicrobial Susceptibility of 41 Burkholderia mallei Isolates From Spontaneous Outbreaks of Equine Glanders in Punjab, Pakistan

  • Abeera Naureen, DVM, MSc

      Affiliations

    • Department of Clinical Medicine and Surgery, University of Veterinary and Animal Sciences, Lahore, Pakistan
    • Corresponding Author InformationReprint requests: Abeera Naureen, Department of Clinical Medicine and Surgery, University of Veterinary and Animal Sciences, Lahore, 54000, Pakistan.
    • ,
  • Muhammad Saqib, DVM, MSc, PhD

      Affiliations

    • Department of Clinical Medicine and Surgery, University of Agriculture, Faisalabad, Pakistan
    • ,
  • Faqeer Muhammad, DVM, MSc, PhD

      Affiliations

    • Department of Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan
    • ,
  • Rehan Ahmad, DVM, MSc, PhD

      Affiliations

    • Remount Depot Mona, Pakistan
    • ,
  • Ghulam Muhammad, DVM, MSc, PhD

      Affiliations

    • Department of Clinical Medicine and Surgery, University of Agriculture, Faisalabad, Pakistan
    • ,
  • Muhammad Nadeem Asi, DVM, MSc

      Affiliations

    • Department of Clinical Medicine and Surgery, University of Agriculture, Faisalabad, Pakistan
    • ,
  • Muhammad Hammad Hussain, DVM, MSc

      Affiliations

    • Department of Clinical Medicine and Surgery, University of Agriculture, Faisalabad, Pakistan
    • ,
  • Laeeq Akbar Lodhi, DVM, MSc, PhD

      Affiliations

    • Department of Animal Reproduction, University of Agriculture, Faisalabad, Pakistan
    • ,
  • Muhammad Sarwar Khan, DVM, MSc, PhD

      Affiliations

    • Department of Clinical Medicine and Surgery, University of Veterinary and Animal Sciences, Lahore, Pakistan
    • ,
  • Francois M. Thibault, PhD

      Affiliations

    • Centre de Recherches du Service de Santé des Armées, La Tronche, France

References 

  1. Waag DM, DeShazer D. Glanders: new insights into an old disease. In:  Lindler LE,  LeBeda FJ,  Korch GW editor. Biological weapons defense: infectious diseases and counter bioterrorism. Totowa, NJ: Humana Press Inc; 2005;p. 209–237
  2. World Organization of Animal Health (OIE). Glanders. In: Manual of diagnostic tests and vaccines for terrestrial animals. Paris: OIE; 2008;Available at: http://www.oie.int/eng/normes/mmanual/2008/pdf/2.05.11_GLANDERS.pdfAccessed July 22, 2009
  3. Smith GR, Pearson AD, Parker MT. Pasteurella infections, tularaemia, glanders and meliodosis. In:  Smith GR,  Easmon CSF editor. Toply and Wilson's principles of bacteriology, virology and immunity. Vol. III. 8th ed. London, UK: Edward Arnold; 1990;
  4. Srinivasan A, Kraus CN, DeShazer D, Beeker PM, Dick JD, Spacek L, et al. Glanders in a military microbiologist. N Engl J Med. 2001;345:256–258
  5. Naureen A, Saqib M, Muhammad G, Hussain MH, Asi MN. Comparative evaluation of Rose Bengal plate agglutination test, mallein and some conventional serological tests for diagnosis of spontaneous equine glanders. J Vet Diagn Invest. 2007;19:362–367
  6. Saqib M, Muhammad G, Athar M, Hussain MH. Glanders. Equine Dis Q. 2003;12:2–3
  7. Pawaiya RVS, Chauhan RS. A review of glanders—a re-emerging zoonosis in India. Indian J Vet Pathol. 2008;32:1–14
  8. Dvorak GD, Spickler AR. Glanders. J Am Vet Med Assoc. 2008;233:570–577
  9. Lehavi O, Aizenstien O, Katz LH, Hourvitz A. Glanders—a potential biological warfare against humans and animals. Harefauh. 2002;140:88–91
  10. Rotz LD, Khan AS, Lillibridge SR, Astroff SM, Hughes JM. Public health assessment of potential biological terrorism agents. Emerg Infect Dis. 2002;2:225–230
  11. Wheelis M. First shots fired in biological warfare. Nature. 1998;395:213
  12. Kenny DJ, Russell P, Rogers D, Eley SM, Titball RW. In vitro susceptibilities of Burkholderia mallei in comparison to those of other pathogenic Burkholderia spp. Antimicrob Agents Chemother. 1999;43:2773–2775
  13. Heine H, England M, Waag D, Byrne W. In vitro antibiotic susceptibilities of Burkholderia mallei (causative agent of glanders) determined by broth microdilution and E-test. Antimicrob Agents Chemother. 2001;45:2119–2121
  14. Thibault FM, Hernandez E, Vidal DR, Girardet M, Cavallo JD. Antibiotic susceptibility of 65 isolates of Burkholderia pseudomallei and Burkholderia mallei to 35 antimicrobial agents. J Antimicrob Chemother. 2004;54:1134–1138
  15. Antonov Iu V, Iliukhin VI, Popovtseva LD, Batmanov VP. Sensitivity of Pseudomonas to currently used antibacterial drugs. Antibiot Khimioter. 1991;36:14–16
  16. Batmanov VP. Sensitivity of Pseudomonas mallei to fluoroquinolones and their efficacy in experimental glanders. Antibiot Khimioter. 1991;36:31–34
  17. Batmanov VP. Treatment of experimental glanders with combinations of sulfazine or sulfamonomethoxine with trimethoprim. Antibiot Khimioter. 1993;38:18–22
  18. Muhammad G, Hoblet KH, Bech-Nielsen S, Jackwood DL, Smith KL. Reproducibility of antibiogram of bovine mammary gland Staphylococci under conditions of repeated subculturing. Zentralbl Veterinarmed B. 1998;45:189–192
  19. Al-Izzi SA, Al-Bassam LS. In vitro susceptibility of Pseudomonas mallei to antimicrobial agents. Comp Immunol Microbiol Infect Dis. 1989;12:5–8
  20. Muhammad G, Khan MZ, Athar M. Clinico-microbiological and therapeutic aspects of glanders in equines. J Equine Sci. 1998;9:93–96
  21. Georgia S, Hornstra H, Pearson T, Schupp J, U'Ren J, Leadem B, et al. Multiple locus variable number tandem repeat analysis reveals fine-scale genetic diversity within the previously indistinguishable organism Burkholderia mallei. Presented at: 46th Annual Meeting of the Arizona-Nevada Branch of the American Society for Microbiology, Northern Arizona University, Flagstaff, AZ; April 14th, 2007:16–17. http://asm.unlv.edu/2007Program.pdf. Accessed August 8, 2009.
  22. Hornstra H, Pearson T, Liguori A, Dale J, Price E, O'Neill M, et al. Molecular epidemiologic analysis of recent outbreaks of glanders in Punjab Province, Pakistan. Emerg Infect Dis. 2009;15:2036–2039
  23. Pathema–Burkholderia: Bioinformatics Resource Center. Burkholderia mallei PRL-20 summary information. [Cited 2009 Apr 08]. Available at: http://pathema.jcvi.org/tigr-scripts/Burkholderia/shared/GenomePage.cgi?org=gbm9. Assessed August 8, 2009.
  24. Ulrich RK, Ulrich MP, Schell MA, Kim HS, DeShazer D. Development of a polymerase chain reaction assay for the specific identification of Burkholderia mallei and differentiation from Burkholderia pseudomallei and other closely related Burkholderiaceae. Diagn Microbiol Infect Dis. 2006;55:37–45
  25. Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing—15th informational supplement. Approved standard, CLSI document M100–S15. Wayne, PA: Clinical and Laboratory Standards Institute; 2005.
  26. Mishankin BN, Goldberg AM. Mechanism of natural penicillin resistance of inducers of glanders and melioidosis. Antibiotiki. 1969;14:1104–1106
  27. Burns JL. Antibiotic resistance of Burkholderia spp. In:  Coenye T,  Vandamme P editor. Burkholderia: molecular microbiology and genomics. Wymondham, Norfolk, UK: Horizon Bioscience; 2006;p. 61–91
  28. Tribuddharat C, Moore RA, Baker P, Woods DE. Burkholderia pseudomallei class a beta-lactamase mutations that confer selective resistance against ceftazidime or clavulanic acid inhibition. Antimicrob Agents Chemother. 2003;47:2082–2087
  29. Turnidge J, Paterson DL. Setting and revising antibacterial susceptibility breakpoints. Clin Microbiol Rev. 2007;20:391–408
  30. Tezok F. Three glanders strains isolated from three patients in 1956 and differing with regard to sensitivity to antibiotics. Internat Congr Microbiol Abstr. 1958;vii:344
  31. Nemato H, Yokobori H, Azuma R. Studies on treatment of antibiotics of experimental acute glanders in guinea pigs. Bull Natl Inst Anim Health. 1961;41:11–20
  32. Ruiz J. Mechanisms of resistance to quinolones: target alterations, decreased accumulation and DNA gyrase protection. J Antimicrob Chemother. 2003;51:1109–1117
  33. Piddock LJ. Mechanisms of fluoroquinolone resistance: an update 1994–1998. Drugs. 1999;58(Suppl 2):11–18
  34. White DG, Piddock LJ, Maurer JJ, Zaho S, Ricci V, Thayer SG. Characterization of fluoroquinolones resistance among veterinary isolates of avian Escherichia coli. Antimicrob Agents Chemother. 2000;44:2897–2899
  35. Viktorv DV, Zakharov IB, Podshivalova MV, Kalinkina EV, Merinova OA, Ageeva NP, et al. High level resistance to fluoroquinolones and cephalosporins in Burkholderia pseudomallei and closely related species. Trans R Soc Trop Med Hyg. 2008;102(Suppl 1):S103–S110
  36. IuG Stepanshin, Manzeniuk IN, Svetoch EA, Volkovoi KI. In vitro development of fluoroquinolone resistance in glanders pathogen. Antibiot Khimioter. 1994;39:30–33
  37. Kaartinen L, Salonen M, lli LA, Pyorala S. Pharmacokinetics of enrofloxacin after single intravenous, intramuscular and subcutaneous injections in lactating cows. J Vet Pharmacol Ther. 1995;18:357–362
  38. Al-Ani FK, Al-Rawashdeh OF, Ali AH, Hassan FK. Glanders in horses: clinical, biochemical and serological studies in Iraq. Vet Archiv. 1998;68:155–162
  39. Lozovaia NA. Sensitivity of Pseudomonas mallei to sulfanilamide combination in vitro. Antibiot Khimioter. 1989;34:48–52
  40. Howe C, Miller WR. Human glanders: report of six cases. Ann Intern Med. 1947;26:93–115
  41. Ansabi M, Minou M. Two cases of chronic human glanders treated with sulfamides. Ann Inst Pasteur. 1951;81:98–102
  42. Godoy D, Randle G, Simpson AJ, Aanensen DM, Pitt TL, Kinoshita R, et al. Multilocus sequence typing and evolutionary relationships among the causative agents of melioidosis and glanders, Burkholderia pseudomallei and Burkholderia mallei. J Clin Microbiol. 2003;41:2068–2079
  43. Harland DN, Dassa E, Titball RW. ATP-binding cassette systems in Burkholderia pseudomallei and Burkholderia mallei. BMC Genomics. 2007;8:83
  44. Moore JD, Skinner MA, Swatman DR. Reactivation of 3-dehydroquinate synthase by lanthanide cations. J Am Chem Soc. 1998;120:7105–7106
  45. Papich MG, Riviere JE. Chloramphenicol and derivatives. In:  Adams HR editors. Veterinary pharmacology and therapeutics, 8th ed. Oxford, UK: Blackwell Publishing Co; 2001;p. 868–876

PII: S0737-0806(10)00058-4

doi: 10.1016/j.jevs.2010.01.056

Journal of Equine Veterinary Science
Volume 30, Issue 3 , Pages 134-140 , March 2010

Article Tools