Table of Contents

From the Guest Editor 

Vision 20/20 -Conquer Laminitis by 202074

Rustin M. Moore, DVM, PhD, DACVS

Reviews 

The Pain State Arising From the Laminitic Horse: Insights Into Future Analgesic Therapies79

Tony L. Yaksh

Overview of What We Know About the Pathophysiology of Laminitis83

Susan C. Eades

Lessons Learned From the Second AAEP Foundation's Equine Laminitis Research Workshop87

James A. Orsini

Abstracts for Podium Presentations 

Laminar Chemokine MRNA Concentrations in Horses With Carbohydrate Overload-Induced Laminitis93

Rafael R. Faleiros

Inflammatory Cytokine Blood Messenger RNA Expression During the Development of Oligofructose-Induced Laminitis in Horses93

Lisa Tadros

Hind Laminar Proinflammatory Response Is Present After Carbohydrate Overload94

Britta S. Leise

Equine Neutrophil Elastase in Plasma, Laminar Tissue, and Skin of Horses Administered Black Walnut Heartwood Extract94

Geoffroy de la Rebière de Pouyade

Prostaglandins E2 and F2α as Inflammatory and Vasoactive Mediators in Black Walnut Heartwood Extract-Induced Equine Laminitis95

Erik Noschka

Proliferative Effects of Insulin on Equine Lamellar Epithelial Cells Mediated by the IGF-1 Receptor96

Simon R. Bailey

Pro-inflammatory Cytokine and Chemokine Expression Profiles of Various Adipose Tissue Depots of Insulin-Resistant and Insulin-Sensitive Light Breed Horses96

Teresa A. Burns

Effects of Short-Term Adaptation to Dietary Carbohydrates on Glucose and Insulin Dynamics in Healthy and Overweight/Obese, Insulin Resistant Mares97

Ray Geor

Insulin Resistance–Comparison of Methods of Fructan Analysis in UK Pasture Grasses97

Annette Longland

Intraosseous Infusion of the Distal Phalanx and Lamellar Microdialysis: New Techniques for Lamellar Drug Delivery and Analysis98

Ali R. Nourian

Gene and Protein Expression of Polysulfated Proteoglycan ECM in the Equine Digital Lamellae98

Le Wang

Localization and Function of Sulfated Proteoglycans in the Equine Digital Laminae99

Erica Pawlak

Temporal Changes in Basement Membrane Proteolysis and Protease Expression During Laminitis Development100

Michelle B. Visser

Pharmacokinetics and Pharmacodynamics of Gabapentin in Horses: A Potentially Useful Analgesic Agent for the Treatment of Laminitis100

Rebecca L. Terry

The Laminitis Discovery Database101

Hannah Galantino-Homer

Abstracts for Poster Presentations 

Modulation of Endothelium-Dependent Relaxation of Equine Digitial Arteries by Insulin and Hypoxia102

Yoel Berhane

Effect of Amine Metabolism by SSAO on Endothelium-Dependent Vasodilatory Responses of Krebs Perfused Equine Digits102

Yoel Berhane

Seasonal Influence on Insulin and Cortisol Results From Overnight Dexamethasone Suppression Tests in Normal and Previously Laminitic Ponies103

Katharine E. Borer

Pharmacokinetics and Pharmacodynamics of Ketanserin103

I.A. Alijuffali

Cellular Proliferation Markers in Lamellar Tissue and Skin Measured by Indirect Immunofluorescence104

Rebecca Carter

Differences in Lamellar Protein Expression During Laminitis Induced by a 48h Prolonged Euglycemic-Hyperinsulinemic Clamp104

Rebecca Carter

Genome-Wide Transcriptome Profiling of Laminar Tissue During Early Stages of Carbohydrate Overload-Induced Equine Laminitis105

Jixin Wang

Whole Genome Functional Analysis of Laminar Tissue From Horses With Laminitis Induced by Prolonged Euglycemic-Hyperinsulinemic Clamp106

Jixin Wang

Clinical and Matrix Metalloproteinase Inhibitory Effects of Pentoxifylline on Carbohydrate Overload Laminitis: Preliminary Results106

Lee Ann Fugler

Isolation of Equine Hoof Epidermal Cells for in Vitro Studies107

Hannah Galantino-Homer

Chemical and Biological Properties of Aqueous Black Walnut Extracts That Contribute to the Pathogenesis of Laminitis107

David J. Hurley

Microarray Analysis of Gene Expression in Laminar Tissue From Horses After Carbohydrate Overload108

So Young Kwon

Laminar Inflammatory Gene Expression in the Carbohydrate Overload Model of Equine Laminitis109

Britta S. Leise

Laminar Regulation of STAT1 and STAT3 in the Black Walnut Extract and Carbohydrate Induced Models of Laminitis109

Britta S. Leise

Insulin Resistance–Hay Analysis and Subsequent Feeding Management110

Annette C. Longland

Use of Insulin Results From Overnight Dexamethasone Suppression Test to Identify Previously Laminitic Ponies110

Nicola J. Menzies-Gow

Deep Digital Flexor Tenotomy as a Treatment for Horses With Chronic Laminitis111

Colin F. Mitchell

Anoxia/Reoxygenation of Equine Endothelial Cells Produce Reactive Oxygen Species: An Oxymetric and Electron Paramagnetic Resonance Investigation112

Geoffrey de la Rebière de Pouyade

Contractile Responses of Laminar Blood Vessels Isolated From Horses Given Black Walnut Heartwood Extract, Carbohydrate Overload or Lipopolysaccharide Infusion112

Tom P. Robertson

Effects of Intracecal Buffer Solution Treatment in Apoptosis of Epidermal Lamellar Cells in Horses With Experimental Laminitis113

Adriana H. Souza

Potential Role of the Toll-Like Receptor Signaling Pathway in Equine Laminitis113

Ashley M. Stokes

Documentation of the Clinical Outcome of Four Laminitis Cases Managed With the Same Hoof Care and Dietary Management Protocol114

Debra R. Taylor

Neutrophil Gelatinase-Associated Lipocalin and Matrix Metalloproteinases in Laminar Tissue from Horses Subjected to Intestinal Obstruction and Treated with Hydrocortisone115

Luciana M. Laskoski

Leukocyte Infiltration and the Role of Interleukin-6 During the Development of Oligofructose-Induced Laminitis115

Michelle B. Visser

Histopathology of Equine Hoof Wall, Skin, and Chestnut in Acute Spontaneous Laminitis116

Ove Wattle

Fructan, Sugar and Starch Concentrations in North American Grass117

Kathryn Watts