Journal of Equine Veterinary Science
Volume 29, Issue 11 , Pages 791-794 , November 2009

Preliminary Study of the Gastric Acidity in Thoroughbred Horses at Rest after Enteral Administration of Esomeprazole Magnesium (Nexium)

  • Marsel C. Pereira, DVM

      Affiliations

    • Department of Animal Morphology and Physiology, Faculty of Agricultural and Veterinary Sciences (FCAV), São Paulo State University (UNESP), Jaboticabal Campus, Jaboticabal, SP, Brazil
    • ,
  • Flavia L. Levy, DVM

      Affiliations

    • Independent Veterinarian, Rua General Goes Monteiro 8, Rio de Janeiro, RJ
    • ,
  • Carlos A.A. Valadão, PhD

      Affiliations

    • Department of Animal Surgery and Clinical Sciences, FCAV, UNESP
    • ,
  • Guilherme C. Ferraz, PhD

      Affiliations

    • Department of Animal Morphology and Physiology, Faculty of Agricultural and Veterinary Sciences (FCAV), São Paulo State University (UNESP), Jaboticabal Campus, Jaboticabal, SP, Brazil
    • ,
  • Antonio Queiroz-Neto, PhD

      Affiliations

    • Department of Animal Morphology and Physiology, Faculty of Agricultural and Veterinary Sciences (FCAV), São Paulo State University (UNESP), Jaboticabal Campus, Jaboticabal, SP, Brazil
    • Corresponding Author InformationReprint requests: Antonio Queiroz-Neto, Via de Acesso Prof. Paulo Donato Castellane, 14884-900, Jaboticabal, SP, Brazil.

References 

  1. Murray M. Equine gastric ulcer syndrome. J Equine Vet Sci. 1999;19:297–304
  2. Bell RJW, Mogg TD, Kingston JK. Equine gastric ulcer syndrome in adult horses: a review. N Z Vet J. 2007;55:1–12
  3. Scarpignato C, Pelosini I, Mario F. Acid suppression therapy: where do we go from here?. Dig Dis. 2006;24:11–46
  4. Mossner J, Caca K. Developments in the inhibition of gastric acid secretion. Eur J Clin Invest. 2005;35:469–475
  5. Merritt AM. The equine stomach: a personal perspective (1963-2003). In: Proceedings 49th Annual Convention of the American Association of Equine Practitioners; 2003.
  6. Lindberg P, Keeling G, Fryklund J, Andersson T, Lundborg P, Carlsson E. Review article: esomeprazole—enhanced bio-availability, specificity for the proton pump and inhibition of acid secretion. Aliment Pharmacol Ther. 2003;17:481–488
  7. Andersson T, Hassan-Alin M, Hasselgren G, Rohss K, Weidolf L. Pharmacokinetic studies with esomeprazole, the (S)-isomer of omeprazole. Clin Pharmacokinet. 2001;40:411–426
  8. Lind T, Rydberg L, Kyleback A. Esomeprazole provides improved acid control vs omeprazole in patients with symptoms of gastro-oesophageal reflux disease. Aliment Pharmacol Ther. 2000;14:861–867
  9. Wilder-Smith C, Claar-Nilsson C, Hasselgren G, Rohss K. Esomeprazole 40 mg provides faster and more effective acid control than rabeprazole 20 mg in patients with symptoms of GERD. J Gastroenterol Hepatol. 2002;17(suppl):612
  10. Metz DC, Miner PB, Heuman DM, Chen Y, Sostek M. Comparison of the effects of intravenously and orally administered esomeprazole on acid output in patients with symptoms of gastro-esophageal reflux disease. Aliment Pharmacol Ther. 2005;22:813–821
  11. Jenkins CC, Blackford JT, Andrews F, Frazier DL, Mattsson H, Olovsson SG, et al. Duration of antisecretory effects of oral omeprazole in horses with chronic gastric cannulae. Equine Vet J. 1992;13(Suppl):89–92
  12. Kalaitzakis E, Bjonsson E. A review of esomeprazole in the treatment of gastroesophageal reflux disease (GERD). Ther Clin Risk Manag. 2007;3:653–663
  13. Murray MJ, Schusser GF. Measurement of 24-h gastric pH using an indwelling pH electrode in horses unfed, fed and treated with ranitidine. Equine Vet J. 1993;25:417–421
  14. Merritt AM. The equine stomach: a personal perspective (1963-2003). In: Proceedings 23rd AAEP Convention; 2009.
  15. Katz PO, Castell DO, Chen Y, Andersson T, Sostek MB. Intragastric acid suppression and pharmacokinetics of twice-daily esomeprazole: a randomized, three-way crossover study. Aliment Pharmacol Ther. 2004;20:399–406

PII: S0737-0806(09)00641-8

doi: 10.1016/j.jevs.2009.10.006

Journal of Equine Veterinary Science
Volume 29, Issue 11 , Pages 791-794 , November 2009

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