Journal of Equine Veterinary Science
Volume 29, Issue 10 , Pages 748-752 , October 2009

Systemic Proteoglycan Deposition Is Not a Characteristic of Equine Degenerative Suspensory Ligament Desmitis (DSLD)

  • Daniel Schenkman, DVM, PhD

      Affiliations

    • Pathobiological Sciences, University of Wisconsin–Madison, School of Veterinary Medicine, Madison, WI
    • Corresponding Author InformationReprint requests: Daniel Schenkman, DVM, PhD, Biomedxplor, LLC, 915 Martin Drive, Marshfield, WI 54449.
    • ,
  • Anibal Armien, DVM, PhD

      Affiliations

    • Veterinary Population Medicine, University of Minnesota, College of Veterinary Medicine, St. Paul, MN
    • ,
  • Roy Pool Jr., DVM, PhD

      Affiliations

    • Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX
    • ,
  • James M. Williams, PhD

      Affiliations

    • Departments of Orthopedic Surgery and Anatomy and Cell Biology, Rush University Medical Center, Chicago, IL
    • ,
  • Ronald D. Schultz, PhD

      Affiliations

    • Pathobiological Sciences, University of Wisconsin–Madison, School of Veterinary Medicine, Madison, WI
    • ,
  • Jorge O. Galante, MD

      Affiliations

    • Departments of Orthopedic Surgery and Anatomy and Cell Biology, Rush University Medical Center, Chicago, IL

References 

  1. Young JH. Degenerative suspensory ligament desmitis. Hoofcare and Lameness. 1993;6–19
  2. Mero JL, Pool RR. Twenty cases of degenerative suspensory ligament desmitis in Peruvian Paso horses. AAEP Proc. 2002;48:329–335
  3. Halper J, Kim B, Khan A, Yoon JH, Mueller POE. Degenerative suspensory ligament desmitis as a systemic disorder characterized by proteoglycan accumulation. Biomed Central Vet Res. 2006;2:12
  4. Mero JL, Scarlett JM. Diagnostic criteria for degenerative suspensory ligament desmitis in Peruvian Paso horses. J Equine Vet Sci. 2005;25:224–228
  5. Rosenberg L. Chemical basis of the histological use of safranin-O in the study of articular cartilage. J Bone Joint Surg. 1971;53A:69–82
  6. Shepard N, Mitchell NJ. The localization of proteoglycan by light and electron microscopy using safranin O: a study of epiphyseal cartilage. Ultrastruct Mol Struct Res. 1976;54:451–460
  7. Shepard N, Mitchell N. Simultaneous localization of proteoglycan by light and electron microscopy using toluidine blue O: a study of epiphyseal cartilage. J Histochem Cytochem. 1976;24:621–629
  8. Junquiera LCU, Bignolas G, Brentani RR. Picrosirius staining plus polarization microscopy, a specific method for collagen detection in tissue sections. Histochem J. 1979;11:447–455
  9. Williams JM, Uebelhart D, Thonar EJ-MA, Kocsis K, Módis L. Alteration and recovery of the spatial orientation of the collagen network of articular cartilage in adolescent rabbits following intra-articular chymopapain injection. Connect Tissue Res. 1996;34:105–117
  10. Dawson B, Trapp RG. Basic and clinical biostatistics. 2nd ed.. East Norwalk, CT: Appleton and Lange; 1994;152
  11. Pool RR. Pathologic changes in tendinitis of athletic horses. In:  Rantanen NW,  Hauser ML editor. Proceedings Dubai International Equine Symposium, March 27–30, 1996. Dubai, United Arab Emirates: MR Rantanen Design; 1996;p. 109–117
  12. Redfern BG, David Wise L, Spence S. Birth defects. Res B Dev Reprod Toxicol. 2007;80:171–176
  13. Szirmai JA. Quantitative approaches to the histochemistry of mucopolysaccharides. J Histochem Cytochem. 1963;11:24–34
  14. Josza L, Szederkenyi G. On the loss of tissue mucopolysaccharides during fixation. Acta Histochem. 1967;26:255–260
  15. Williams JM, Ongchi DR, Thonar EJ-MA. Repair of articular cartilage injury following intra-articular chymopapain induced matrix proteoglycan loss. J Orthop Res. 1993;11:705–716
  16. Vasseur PB, Pool RR, Arnoczky SP, Lau RE. Correlative biomechanical and histologic study of the cranial cruciate ligament in dogs. Am J Vet Res. 1985;46:1842–1854
  17. Riley G. Tendinopathy: from basic science to treatment. Nat Clin Pract Rheumatol. 2008;4:82–89
  18. Shim JW, Elder SH. Influence of cyclic hydrostatic pressure on fibrocartilaginous metaplasia of Achilles tendon fibroblasts. Biomech Model Mechanobiol. 2006;5:247–252
  19. Archambault JM, Jelinsky SA, Lake SP, Hill AA, Glaser DL, Soslowsky LJ. Rat supraspinatus tendon expresses cartilage markers with overuse. J Orthop Res. 2007;25:617–624

PII: S0737-0806(09)00573-5

doi: 10.1016/j.jevs.2009.07.015

Journal of Equine Veterinary Science
Volume 29, Issue 10 , Pages 748-752 , October 2009

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