Journal of Equine Veterinary Science
Volume 29, Issue 8 , Pages 627-632 , August 2009

Effect of Competition on Nitric Oxide, Carbon Monoxide, and Cyclic Guanosine Monophosphate Levels in Training Horses

  • Gonzalo Marañon, DVM, PhD

      Affiliations

    • Horsepital SL, Madrid, Spain
  • ,
  • Bárbara Muñoz-Escassi, DVM, PhD

      Affiliations

    • Horsepital SL, Madrid, Spain
  • ,
  • William Manley, DVM, PhD

      Affiliations

    • Horsepital SL, Madrid, Spain
  • ,
  • Cruz García, PharmD, PhD

      Affiliations

    • Department of Biochemistry and Molecular Biology, School of Medicine, Complutense University, Madrid, Spain
  • ,
  • Rosa León, DVM

      Affiliations

    • Horsepital SL, Madrid, Spain
  • ,
  • Begoña Olábarri, DVM

      Affiliations

    • Horsepital SL, Madrid, Spain
  • ,
  • Patricia Cayado, DVM, PhD

      Affiliations

    • Horsepital SL, Madrid, Spain
  • ,
  • Cristina Domínguez, DVM

      Affiliations

    • Horsepital SL, Madrid, Spain
  • ,
  • Mercedes Sánchez de la Muela, DVM, PhD

      Affiliations

    • Department of Animal Medicine and Surgery, School of Veterinary, Complutense University, Madrid, Spain
  • ,
  • Maria Suarez, DVM, PhD

      Affiliations

    • Department of Animal Medicine and Surgery, School of Veterinary, Complutense University, Madrid, Spain
  • ,
  • Elena Vara, BD, PhD

      Affiliations

    • Department of Biochemistry and Molecular Biology, School of Medicine, Complutense University, Madrid, Spain
    • Corresponding Author InformationReprint requests: Prof. E. Vara, Department of Biochemistry and Molecular Biology, School of Medicine, Complutense University, Avda. Complutense s/n 28040 Madrid, Spain.

References 

  1. Akova B, Sürmen-Gür E, Gür H, Dirican M, Sarandöl E, Kücükoglu S. Exercise induced oxidative stress and muscle performance in healthy women: role of vitamin E supplementation and endogenous oestradiol. Eur J Appl Physiol. 2001;84:141–147
  2. Jackson M. Handbook of oxidants and antioxidants in exercise. Amsterdam: Elsevier; 2000;
  3. Heunks L, Vina J, Van Herwaarden CL, Folgering HT, Gimeno A, Dekhuijzen PN. Xanthine oxidase is involved in exercise-induced oxidative stress in chronic obstructive pulmonary disease. Am J Physiol. 1999;277:697–704
  4. Cooper C, Vollaard NBJ, Chouery T, Wilson MT. Exercise, free radicals and oxidative stress. Biochem Soc Trans. 2001;30:280–285
  5. Lee J, Clarkson PM. Plasma creatine kinase activity and glutathione after eccentric exercise. Med Sci Exports Exerc. 2003;35:930–936
  6. Reiter R. Oxidative damage in the central nervous system: protection by melatonin. Prog Neurobiol. 1998;56:359–384
  7. Reiter R, Tan DX, Cabrera J, D'Arpa D, Sainz RM, Mayo JC, et al. The oxidant/antioxidant network: role of melatonin. Biol Signals Recept. 1999;8:56–63
  8. Ryter S, Otterbein LE, Morse D, Choi AM. Heme oxygenase/carbon monoxide signalling pathways: regulation and functional significance. Mol Cell Biochem. 2002;234–235249–263
  9. Baranano D, Snyder SH. Neural roles for heme oxygenase: contrast to nitric oxide synthase. Proc Natl Acad Sci. 2001;98:10996–11002
  10. Balon T, Nadler JL. Nitric oxide release is present from incubated skeletal muscle preparations. J Appl Physiol. 1994;77:2519–2521
  11. Nakane M, Schmidt MHHHW, Pollack JS, Förstermann U, Murad F. Cloned human nitric oxide synthase is highly expressed in skeletal muscle. FEBBS Lett. 1993;316:175–180
  12. Matsumoto A, Hirata Y, Momomura S, Fujita H, Yao A, Sata M, et al. Increased nitric oxide production during exercise. Lancet. 1994;343:849–850
  13. Patil R, DiCarlo SE, Collins HL. Acute exercise enhances nitric oxide modulation of vascular response to phenylephrine. Am J Physiol (Heart Circ Physiol 34). 1993;265:H1184–H1118
  14. Guo X, Shin VY, Cho CH. Modulation of heme oxigenase in tissue injury and its implication in protection against gastrointestinal diseases. Life Sci. 2001;69:3113–3119
  15. Henningsson R, Alm P, Lundquist I. Evaluation of islet heme oxygenase-CO and nitric oxide synthase-NO pathways during acute endotoxemia. Am J Physiol Cell Physiol. 2001;280:C1242–C1254
  16. Otterbein L, Bach FH, Alam J, Soares M, Tao Lu H, Wysk M, et al. Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway. Nat Med. 2000;6:422–428
  17. Almeida A, Cidad P, Delgado-Esteban M, Fernández E, García-Nogales P, Bolaños JP. Inhibition of mitochondrial respiration by nitric oxide: Its role in glucose metabolism and neuroprotection. J Neurosci Res 2004. 2004;79:166–171
  18. Bolaños J, Peuchen S, Heales SJR, Land JM, Clark JB. Nitric oxide-mediated inhibition of the mitochondrial respiratory chain in cultured astrocytes. J Neurochem. 1994;63:910–916
  19. Le Goffe C, Vallette G, Charrier L, Candelon T, Bou-Hanna C, Bouhours JF, et al. Metabolic control of resistance of human epithelial cells to H2O2 and NO stresses. Biochem J. 2002;364:349–359
  20. Etgen GJ, Fryburg DA, Gibbs EM. Nitric oxide stimulates skeletal muscle glucose transport through a calcium/contraction- and phosphatidylinositol-3-kinase-independent pathway. Diabetes. 1997;46:1915–1919
  21. Frye RL, Hajduch E, Rencurel F, Salt IP, Hundal HS, Hardie DG, et al. Activation of glucose transport by AMP-activated protein kinase via stimulation of nitric oxide synthase. Diabetes. 2000;49:1978–1985
  22. Boveris A, Navarro A. The role of mitochondrial nitric oxide synthase in inflammation and septic shock. Free Radic Biol Med. 2002;339:1186–1193
  23. Marañón G, Muñoz-Escassi B, Manley W, García C, Cayado P, Sánchez de la Muela M, et al. The effect of methyl sulphonyl methane supplementation on biomarkers of oxidative stress in sport horses following jumping exercise. Acta Vet Scand. 2008;50:45–53
  24. Pescatello L, Fagard R, Farquhar WB, Kelley GA, Ray CA. Exercise and hypertension. Med Sci Sports Exerc. 2004;36:533–553
  25. Coburn R, Blakemore WS, Foster RE. Endogenous carbon monoxide production in man. J Clin Invest. 1963;42:1172–1178
  26. Arias-Díaz J, Vara E, Garcia C, Villa N, Balibrea JL. Evidence for a cGMP-dependent carbon monoxide-mediated signalling system in the regulation of TNF production by human pulmonary macrophages. Arch Surg. 1995;130:1287–1293
  27. Arias-Díaz J, Villa N, Hernández J, Vara E, Balibrea JL. Carbon monoxide contributes to the cytokine-induced inhibition of surfactant synthesis by human type II pneumocytes. Arch Surg. 1997;132:1352–1360

PII: S0737-0806(09)00545-0

doi: 10.1016/j.jevs.2009.07.004

Journal of Equine Veterinary Science
Volume 29, Issue 8 , Pages 627-632 , August 2009