Journal of Equine Veterinary Science
Volume 29, Issue 6 , Pages 540-546 , June 2009

Prevalence of Gastric Ulcerations in Horses with Colic

  • Tara S. Rabuffo, DVM, ACVS

      Affiliations

    • Smoketown Veterinary Hospital, Smoketown, PA
    • ,
  • Eileen S. Hackett, DVM, MS, ACVS

      Affiliations

    • Department of Clinical Sciences, College of Veterinary and Biomedical Sciences, Colorado State University, Ft Collins, CO
    • ,
  • Nora Grenager, VMD

      Affiliations

    • Steinbeck Country Equine Clinic, Salinas, CA
    • ,
  • Raymond Boston, PhD

      Affiliations

    • Department of Clinical Studies, University of Pennsylvania, School of Veterinary Medicine, Kennett Square, PA
    • ,
  • James A. Orsini, DVM, ACVS

      Affiliations

    • Department of Clinical Studies, University of Pennsylvania, School of Veterinary Medicine, Kennett Square, PA
    • Corresponding Author InformationReprint requests: James A. Orsini, DVM, ACVS, University of Pennsylvania, School of Veterinary Medicine, New Bolton Center, 382 West Street Road, Kennett Square, PA 19348.

References 

  1. Hammond CJ, Mason DK, Watkins KL. Gastric ulceration in mature Thoroughbred horses. Equine Vet J. 1986;18:284–287
  2. Murray MJ. Gastric ulceration in horses: 91 cases (1987–1990). J Am Vet Med Assoc. 1992;201:117–120
  3. Murray MJ. Endoscopic appearance of gastric lesions in foals: 94 cases (1987–1990). J Am Vet Med Assoc. 1989;8:1135–1141
  4. Rebhun WC, Dill SG, Power HT. Gastric ulcers in foals. J Am Vet Med Assoc. 1982;180:404–407
  5. Murray MJ, Murray CM, Sweeney HJ, Digby NJ, Stoneham SJ. Prevalence of gastric lesions in foals without signs of gastric disease: an endoscopic survey. Equine Vet J. 1990;22:6–8
  6. Rabuffo TS, Orsini JA, Sullivan E, Engiles J, Norman T, Boston R. Association between age or sex and prevalence of gastric ulceration in Standardbred racehorses in training. J Am Vet Med Assoc. 2002;221:1156–1159
  7. Dionne RM, Vrins AA, Doucet MY. Gastric ulcers in Standardbred racehorses: prevalence, lesion description, and risk factors. J Vet Intern Med. 2003;17:218–222
  8. Bertone JJ. Prevalence of gastric ulcers in elite, heavy use western performance horses. Proceedings 46th American Association of Equine Practitioners, 2000;46:356–259.
  9. McClure SR, Carithers DS, Gross SJ, Murray MJ. Gastric ulcer development in horses in a simulated show or training environment. J Am Vet Med Assoc. 2005;227:775–777
  10. Chameroy KA, Nadeau JA, Bushmich SL, Dinger JE, Hoagland TA, Saxton AM. Prevalence of non-glandular gastric ulcers in horses involved in a university riding program. J Equine Vet Sci. 2006;26:207–211
  11. Murray M, Grodinsky C, Anderson CS, Radue PF, Schmidt GR. Gastric ulcers in horses: a comparison of endoscopic findings in horses with and without clinical signs. Equine Vet J. 1989;7:68–72
  12. Vatistas NJ, Snyder RJ, Carlson G, Johnson B, Arthur RM, Thurmond M, et al. Epidemiological study of gastric ulceration in the Thoroughbred racehorse: 202 cases (1992–1993). Proc Am Assoc Equine Pract. 1994;40:125–126
  13. Orsini JA, Pipers FS. Endoscopic evaluation of the relationship between training, racing, and gastric ulcers. Vet Surg. 1997;26:424
  14. Murray MJ, Schusser GF, Pipers FS, Gross SJ. Factors associated with gastric lesions in Thoroughbred racehorses. Equine Vet J. 1996;28:368–374
  15. Vatistas NJ, Snyder JR, Carlson G, Johnson B, Arthur RM, Thumond M, et al. Cross-sectional study of gastric ulcers of the squamous mucosa in Thoroughbred racehorses. Equine Vet J. 1999;29:34–39
  16. Murray MJ. Pathophysiology of peptic disorders in foals and horses: a review. Equine Vet J. 1999;29:14–18
  17. Lorenzo-Figueras M, Merritt AM. Effects of exercise on gastric volume and pH in the proximal portion of the stomach of horses. Am J Vet Res. 2002;63:1481–1487
  18. Andrews FM, Buchanan BR, Elliott SB, Al-Jassim RAM, McGowan CM, Saxton AM. In vitro effects of hydrochloric and lactic acids on bioelectric properties of equine gastric squamous mucosa. Equine Vet J. 2008;40:301–305
  19. Merritt AM. Normal equine gastroduodenal secretion and motility. Equine Vet J. 1999;29:7–13
  20. Cecceralli C, Pedini V, Garguilo AM. Serotonin-containing cells in the horse gastrointestinal tract. Anat Histol Embryol. 1995;24:97–99
  21. Cho CH, Ogle CW. The inhibitory action of 5-hydroxytryptamine on gastric secretory function in rats. Br J Pharmacol. 1986;87:371–377
  22. Garner A, Flemstrom G, Allen A, Heylings JR, McQueen S. Gastric mucosal protective mechanisms: role of epithelial bicarbonate and mucus secretions. Scand J Gastroenterol. 1984;19:79–86
  23. Jaffe BM, Kopen DF, Lazan DW. Endogenous serotonin in the control of gastric acid secretion. Surgery. 1977;82:156–163
  24. Kitamura N, Yamada J, Calingasan NY, Yamashita T. Immunocytochemical distribution of endocrine cells in the gastrointestinal tract of the horse. Equine Vet J. 1984;16:103–107
  25. Murray MJ. Gastroduodenal ulceration. In:  Reed SM,  Bayly WM editor. Equine internal medicine. Philadelphia: W.B. Saunders; 1998;p. 615–623
  26. Hatt JF, Manson PJ. Inhibition of gastric acid secretion by epidermal growth factor. Biochem J. 1988;25:789
  27. Andrews FM, Nadeau JA. Clinical syndromes of gastric ulceration in foals and mature horses. Equine Vet J. 1999;29:30–39
  28. Campbell-Thompson ML, Merritt AM. Basal and pentagastrin stimulated gastric secretion in young horses. Am J Physiol. 1990;259:R1259–R1266
  29. Sanchez LC, Murray MJ, Merritt AM. Effect of omeprazole paste on intragastric pH in clinically normal neonatal foals. Am J Vet Res. 2004;65:1039–1041
  30. Murray MJ. Equine model of inducing ulceration in alimentary squamous epithelial mucosa. Dig Dis Sci. 1994;39:2530–2535
  31. Murray MJ, Schusser GF. Measurement of 24-h gastric pH using an indwelling pH electrode in horses unfed, fed, and treated with ranitidine. Equine Vet J. 1993;25:417–421
  32. Geor RJ, Harris PA. How to minimize gastrointestinal disease associataed with carbohydrate nutrition in horses. Proceedings 53rd Annual Convention American Association of Equine Practitioners 2007;178–185.
  33. Feige K, Furst A, Eser MW. Influences of environment, feeding and use on equine health with emphasis on respiratory and gastrointestinal diseases. Schweizer Archiv Fuer Tierheilkunde. 2002;144:348–355
  34. Kahrilas PJ, Dodds WJ, Hogan WJ, Kern M, Arndorfer RC, Reece A. Oesophageal peristaltic dysfunction in peptic esophagitis. Gastroenterology. 1986;91:897–904
  35. Berschneider HM, Blikslager AT, Roberts MC. Role of duodenal reflux in nonglandular gastric ulcer disease of the mature horse. Equine Vet J. 1999;29:24–29
  36. Miller TA. Protective effects of prostaglandins against mucosal damage: current knowledge and proposed mechanisms. Am J Physiol. 1983;245:G601–G623
  37. Kauffman G. The role of prostaglandins in the regulation of gastric mucosal blood flow. Prostaglandins. 1981;21:33–38
  38. Mo Furr, Murray MJ, Ferguson DC. The effects of stress on gastric ulceration, T3, T4, rT3, and cortisone in neonatal foals. Equine Vet J. 1992;24:37–40
  39. Mertz HR, Walsh JH. Peptic ulcer pathophysiology. Med Clin North Am. 1991;75:799–814
  40. Brzozowski T, Konturek PCh, Konturek SJ, Sliwowski Z, Drozdowicz D, Zaczek M, et al. Role of L-arginine, a substrate for nitric oxide-synthase, in gastroprotection and ulcer healing. J Gastro. 1997;32:442–452
  41. Andrews FM, Reinemeyer CR, McCracken MD, Blackford JT, Nadeau JA, Saabye L, et al. Comparison of endoscopic, necropsy and histology scoring of equine gastric ulcers. Equine Vet J. 2002;34:475–478
  42. Orsini JA, Hackett ES, Grenager N. The effect of exercise on equine gastric ulcer syndrome in the Thoroughbred and Standardbred athlete. J Equine Vet Sci. 2009;29:167–171
  43. Murray MJ, Eichorn ES. Effects of intermittent feed deprivation, intermittent feed deprivation with ranitidine administration, and stall confinement with ad libitum access to hay on gastrin ulceration in horses. Am J Vet Res. 1996;57:1599–1603
  44. MacAllister CG, Morgan SJ, Borne AT, Pollet RA. Comparison of adverse effects of phenylbutazone, flunixin meglumine, and ketoprofen in horses. J Am Vet Med Assoc. 1993;202:71–77
  45. Lester GD, Smith RL, Robertson ID. Effect of treatment with omeprazole or ranitidine on gastric squamous ulceration in racing Thoroughbreds. J Am Vet Med Assoc. 2005;227:1636–1639
  46. Orsini JA, Haddock M, Stine L, Sullivan EK, Rabuffo TS, Smith G. Odds of moderate or severe gastric ulceration in racehorses receiving antiulcer medications. J Am Vet Med Assoc. 2003;223:336–339
  47. Andrews FM, Sifferman RL, Bernard W. Efficacy of omeprazole paste in the treatment and prevention of gastric ulcers in horses. Equine Vet J. 1999;29:81–86
  48. McClure SR, Glickman LT, Glickman NW. Prevalence of gastric ulcers in show horses. J Am Vet Med Assoc. 1999;215:1130–1133

PII: S0737-0806(09)00488-2

doi: 10.1016/j.jevs.2009.05.005

Journal of Equine Veterinary Science
Volume 29, Issue 6 , Pages 540-546 , June 2009

Article Tools

* Image Usage & Resolution