Journal of Equine Veterinary Science
Volume 29, Issue 4 , Pages 197-205 , April 2009

Application of Exogenous Esterified Hyaluronan to Equine Distal Limb Wounds

  • Stefan H. Witte, DVM

      Affiliations

    • Department of Large Animal Medicine, University of Georgia, Athens, GA
    • Corresponding Author InformationReprint requests: Stefan H. Witte, DVM, Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA 30602
    • ,
  • Abayomi K. Olaifa, DVM, MS

      Affiliations

    • Department of Surgery and Reproduction, University of Ibadan, Nigeria
    • ,
  • Andrew J. Lewis, DVM

      Affiliations

    • Department of Large Animal Medicine, University of Georgia, Athens, GA
    • ,
  • Randy B. Eggleston, DVM

      Affiliations

    • Department of Large Animal Medicine, University of Georgia, Athens, GA
    • ,
  • Jaroslava Halper, MD, PhD

      Affiliations

    • Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA
    • ,
  • Manfred Kietzmann, Prof. Dr med vet

      Affiliations

    • Institute for Pharmacology and Toxicology, Hannover School of Veterinary Medicine, Hannover, Germany
    • ,
  • Wolfgang Baeumer, Priv. Doz. Dr med vet

      Affiliations

    • Institute for Pharmacology and Toxicology, Hannover School of Veterinary Medicine, Hannover, Germany
    • ,
  • P.O. Eric Mueller, DVM, PhD

      Affiliations

    • Department of Large Animal Medicine, University of Georgia, Athens, GA

References 

  1. Walton GS, Neal PA. Observations on wound healing in the horse. The role of wound contraction. Equine Vet J. 1972;4:93–97
  2. Theoret C. Wound repair. In:  Auer J,  Stick J editor. Equine surgery. 3rd ed. Philadelphia: J.B. Saunders; 2006;p. 44–62
  3. Roberts A, Sporn M. Transforming growth factor-β. In:  Clark RAF editors. The molecular and cellular biology of wound repair. 2nd ed. New York: Plenum Press; 1996;p. 275–308
  4. O'Kane S, Ferguson MW. Transforming growth factor-β s and wound healing. Int J Biochem Cell Biol. 1997;29:63–78
  5. Zhang K, Garner W, Cohen L, Rodriguez J, Phan S. Increased types I and III collagen and transforming growth factor-β 1 mRNA and protein in hypertrophic burn scar. J Invest Dermatol. 1995;104:750–754
  6. Halper J, Griffin A, Hu W, Jung C, Zhang J, Pan H, et al. In vitro culture decreases the expression of TGFβ, Hsp47 and type I procollagen and increases the expression of CTGF in avian tendon explants. J Musculoskelet Neuronal Interact. 2005;5:53–63
  7. Halper J, Jung C, Perry A, Suliman H, Hill MP, Scheithauer B. Expression of TGFα in meningiomas. J Neurooncol. 1999;45:127–134
  8. Yvorchuk-St Jean K, Gaughan E, St Jean G, Frank R. Evaluation of a porous bovine collagen membrane bandage for management of wounds in horses. Am J Vet Res. 1995;56:1663–1667
  9. Theoret CL, Barber SM, Moyana TN, Gordon JR. Preliminary observations on expression of transforming growth factors β1 and β3 in equine full-thickness skin wounds healing normally or with exuberant granulation tissue. Vet Surg. 2002;31:266–273
  10. Berry DB, Sullins KE. Effects of topical application of antimicrobials and bandaging on healing and granulation tissue formation in wounds of the distal aspect of the limbs in horses. Am J Vet Res. 2003;64:88–92
  11. Howard RD, Stashak TS, Baxter GM. Evaluation of occlusive dressings for management of full-thickness excisional wounds on the distal portion of the limbs of horses. Am J Vet Res. 1993;54:2150–2154
  12. Gomez JH, Schumacher J, Lauten SD, Sartin EA, Hathcock TL, Swaim SF. Effects of three biologic dressings on healing of cutaneous wounds on the limbs of horses. Can J Vet Res. 2004;68:49–55
  13. Dart AJ, Cries L, Jeffcott LB, Hodgson DR, Rose RJ. Effects of 25% propylene glycol hydrogel (Solugel) on second intention wound healing in horses. Vet Surg. 2002;31:309–313
  14. Bullard KM, Longaker MT, Lorenz HP. Fetal wound healing: current biology. World J Surg. 2003;27:54–61
  15. ocono JA, Ehrlich HP, Keefer KA, Krummel TM. Hyaluronan induces scarless repair in mouse limb organ culture. J Pediatr Surg. 1998;33:564–567
  16. ocono JA, Krummel TM, Keefer KA, Allison GM, Paul H. Repeated additions of hyaluronan alters granulation tissue deposition in sponge implants in mice. Wound Repair Regen. 1998;6:442–448
  17. Hu M, Sabelman EE, Cao Y, Chang J, Hentz VR. Three-dimensional hyaluronic acid grafts promote healing and reduce scar formation in skin incision wounds. J Biomed Mater Res B Appl Biomater. 2003;67:586–592
  18. Benedetti L, Cortivo R, Berti T, Pea F, Mazzo M, Moras M, et al. Biocompatibility and biodegradation of different hyaluronan derivatives (Hyaff) implanted in rats. Biomaterials. 1993;14:1154–1160
  19. Davidson JM, Nanney LB, Broadley KN, Whitsett JS, Aquino AM, Beccaro M, et al. Hyaluronate derivatives and their application to wound healing: preliminary observations. Clin Mater. 1991;8:171–177
  20. Gilbert ME, Kirker KR, Gray SD, Ward PD, Szakacs JG, Prestwich GD, et al. Chondroitin sulfate hydrogel and wound healing in rabbit maxillary sinus mucosa. Laryngoscope. 2004;114:1406–1409
  21. Kirker KR, Luo Y, Morris SE, Shelby J, Prestwich GD. Glycosaminoglycan hydrogels as supplemental wound dressings for donor sites. J Burn Care Rehab. 2004;25:276–286
  22. Kirker KR, Luo Y, Nielson JH, Shelby J, Prestwich GD. Glycosaminoglycan hydrogel films as bio-interactive dressings for wound healing. Biomaterials. 2002;23:3661–3671
  23. Luo Y, Kirker KR, Prestwich GD. Cross-linked hyaluronic acid hydrogel films: new biomaterials for drug delivery. J Control Release. 2000;69:169–184
  24. Laurent T. The biology of hyaluronan. Introduction. Ciba Found Symposium. 1989;143:1–20
  25. Zhao XB, Fraser JE, Alexander C, Lockett C, White BJ. Synthesis and characterization of a novel double crosslinked hyaluronan hydrogel. J Mater Sci Mater Med. 2002;13:11–16
  26. Bertone AL, Sullins KE, Stashak TS, Norrdin RW. Effect of wound location and the use of topical collagen gel on exuberant granulation tissue formation and wound healing in the horse and pony. Am J Vet Res. 1985;46:1438–1444
  27. Ballard K, Cantor AJ. Treating recalcitrant diabetic wounds with hyaluronic acid: a review of patients. Ostomy Wound Manage. 2003;49:37–3840, 42, passim
  28. Anderson I. The properties of hyaluronan and its role in wound healing. Prof Nurse. 2001;17:232–235
  29. Kobayashi H, Terao T. Hyaluronic acid-specific regulation of cytokines by human uterine fibroblasts. Am J Physiol. 1997;273:C1151–C1159
  30. West DC, Hampson IN, Arnold F, Kumar S. Angiogenesis induced by degradation products of hyaluronic acid. Science. 1985;228:1324–1326
  31. Slevin M, Krupinski J, Gaffney J, Matou S, West D, Delisser H, et al. Hyaluronan-mediated angiogenesis in vascular disease: uncovering RHAMM and CD44 receptor signaling pathways. Matrix Biol. 2007;26:58–68
  32. Brown JA. The role of hyaluronic acid in wound healing's proliferative phase. J Wound Care. 2004;13:48–51
  33. Lees VC, Fan TP, West DC. Angiogenesis in a delayed revascularization model is accelerated by angiogenic oligosaccharides of hyaluronan. Lab Invest. 1995;73:259–266
  34. Trabucchi E, Pallotta S, Morini M, Corsi F, Franceschini R, Casiraghi A, et al. Low molecular weight hyaluronic acid prevents oxygen free radical damage to granulation tissue during wound healing. Int J Tissue React. 2002;24:65–71
  35. Theoret CL, Barber SM, Moyana TN, Gordon JR. Expression of transforming growth factor β(1), β(3), and basic fibroblast growth factor in full-thickness skin wounds of equine limbs and thorax. Vet Surg. 2001;30:269–277
  36. De Martin I, Theoret CL. Spatial and temporal expression of types I and II receptors for transforming growth factor-β in normal equine skin and dermal wounds. Vet Surg. 2004;33:70–76
  37. Steel CM, Robertson ID, Thomas J, Yovich JV. Effect of topical rh-TGF-β1 on second intention wound healing in horses. Aust Vet J. 1999;734–737
  38. Ohnemus P, von Rechtenberg BV, Arvinte T, El-Warrak A, Akins M, Plocki K, et al. Application of TGF- β3 on experimentally created circular wounds in horses. Proceedings 8th Annual Scientific Meeting of the European Congress of Veterinary Surgeons. 1999;28:216
  39. Theoret CL, Barber SM, Gordon JR. Temporal localization of immunoreactive transforming growth factor-β1 in normal equine skin and in full-thickness dermal wounds. Vet Surg. 2002;31:274–280
  40. Price R. MG Berry, Harshad AN. Hyaluronic acid: the scientific and clinical evidence. J Plastic Reconstruct Aesthetic Surg. 2007;60:1110–1119
  41. Brumbaugh GW. Use of antimicrobials in wound management. Vet Clin North Am: Equine Pract. 2005;21:63–75
  42. Marshall DA, Mertz PM, Eaglstein WH. Occlusive dressings. Does dressing type influence the growth of common bacterial pathogens?. Arch Surg. 1990;125:1136–1139
  43. Yao F, Visovatti S, Johnson CS, Chen M, Slama J, Wenger A, et al. Age and growth factors in porcine full-thickness wound healing. Wound Repair Regen. 2001;9:371–377
  44. Liao YH, Jones SA, Forbes B, Martin GP, Brown MB. Hyaluronan: pharmaceutical characterization and drug delivery. Drug Deliv. 2005;12:327–342
  45. Caravaggi C, De Giglio R, Pritelli C, Sommaria M, Dalla Noce S, Faglia E, et al. HYAFF 11-based autologous dermal and epidermal grafts in the treatment of noninfected diabetic plantar and dorsal foot ulcers: a prospective, multicenter, controlled, randomized clinical trial. Diabetes Care. 2003;26:2853–2859
  46. Esposito G, Gravante G, Filingeri V, Delogu D, Montone A. Use of hyaluronan dressings following dermabrasion avoids escharectomy and facilitates healing in pediatric burn patients. Plast Reconstr Surg. 2007;119:2346–2347
  47. Costagliola M, Agrosi M. Second-degree burns: a comparative, multicenter, randomized trial of hyaluronic acid plus silver sulfadiazine versus. silver sulfadiazine alone. Curr Med Res Opin. 2005;21:1235–1240
  48. Turner NJ, Kielty CM, Walker MG, Canfield AE. A novel hyaluronan-based biomaterial (Hyaff-11) as a scaffold for endothelial cells in tissue engineered vascular grafts. Biomaterials. 2004;25:5955–5964
  49. Sanginario V, Ginebra MP, Tanner KE, Planell J, Ambrosio L. Biodegradable and semi-biodegradable composite hydrogels as bone substitutes: morphology and mechanical characterization. J Mater Sci Mater Med. 2006;17:447–454
  50. Weindl G, Schaller M, Schäfer-Korting M, Korting HC. Hyaluronic acid in the treatment and prevention of skin diseases: molecular biological, pharmaceutical and clinical aspects. Skin Pharmacol Physiol. 2004;17:207–213

 As presented at the 10th Annual Scientific Meeting of the Veterinary Wound Healing As presented at the 10th Annual Meeting of the European Veterinary Wound Healing Association, Berlin, 2007

PII: S0737-0806(09)00036-7

doi: 10.1016/j.jevs.2009.02.007

Journal of Equine Veterinary Science
Volume 29, Issue 4 , Pages 197-205 , April 2009

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