Journal of Equine Veterinary Science
Volume 29, Issue 2 , Pages 105-114 , February 2009

Laminitis in Horses: Through the Lens of Systems Theory

References 

  1. Anonymous. Systems theory. Available at: Wikipedia, http://en.wikipedia.org/wiki/Systems_theory. Accessed December 3, 2008.
  2. Anonymous. Glossary of systems theory. Available at: Wikipedia, http://en.wikipedia.org/wiki/Glossary_of_systems_theory. Accessed December 3, 2008.
  3. Pollitt CC. Anatomy and physiology of the inner hoof wall. Clin Techn Equine Pract. 2004;3:3–21
  4. Moore RM, Eades SC, Stokes AM. Evidence for vascular and enzymatic events in the pathophysiology of acute laminitis: which pathway is responsible for initiation of this process in horses?. Equine Vet J. 2004;36:204–209
  5. Anonymous. Open system (systems theory). Available at: Wikipedia, http://en.wikipedia.org/wiki/Open_system_(systems_theory). Accessed December 3, 2008.
  6. Clutterbuck AL, Harris P, Allaway D, Mobasheri A. Matrix metalloproteinases in inflammatory pathologies of the horse. Vet Journal. 2008;e-publication in advance of print
  7. Kyaw-Tanner MT, Wattle O, van Eps AW, Pollitt CC. Equine laminitis: membrane type matrix metalloproteinase-1 (MMP-14) is involved in acute phase onset. Equine Vet J. 2008;40:482–487
  8. Pollitt CC. Equine laminitis. Clin Techn Equine Pract. 2004;3:34–44
  9. Wattle O, Pollitt CC. Lamellar metabolism. Clinical Techniques in Equine Practice. 2004;13:22–33
  10. Asplin KE, McGowan CM, Pollitt CC, et al. Role of insulin in glucose uptake in the equine hoof. Proceedings American College of Veterinary Internal Medicine Forum, Seattle, WA; 2007.
  11. Redden RF. Preventing laminitis in the contralateral limb of horses with nonweight-bearing lameness. Clin Techn Equine Pract. 2004;3:57–63
  12. van Eps AW, Walters LJ, Baldwin GI, McGarry Mark, Christopher C, Pollitt . Distal limb cryotherapy for the prevention of acute laminitis. Clin Techn Equine Pract. 2004;3:64–70
  13. Asplin KE, Sillence MN, Pollitt CC, McGowan CM. Induction of laminitis by prolonged hyperinsulinaemia in clinically normal ponies. Vet Journal. 2007;174:530–535
  14. Peroni JF, Moore JN, Noschka E, Grafton ME, Aceves-Avila M, Lewis SJ, et al. Predisposition for venoconstriction in the equine laminar dermis: implications in equine laminitis. J Appl Physiol. 2006;100:759–763
  15. Robertson TP, Moore JN, Noschka E, Lewis TH, Lewis SJ, Peroni JF. Evaluation of activation of protein kinase C during agonist-induced constriction of veins isolated from the laminar dermis of horses. Am J Vet Res. 2007;68:664–669
  16. Mungall BA, Kyaw-Tanner M, Pollitt CC. In vitro evidence for a bacterial pathogenesis of equine laminitis. Vet Microbiol. 2001;79:209–223
  17. Crawford C, Sepulveda MF, Elliot J, Harris PA, Bailey SR. Dietary fructan carbohydrate increases amine production in the equine large intestine: implications for pasture-associated laminitis. J Anim Sci. 2007;85:2949–2958
  18. Loftus JP, Black SJ, Pettigrew A, Abrahamsen EJ, Belknap JK. Early laminar events involving endothelial activation in horses with black walnut-induced laminitis. Am J Vet Res. 2007;68:1205–1211
  19. Parsons CS, Orsini JA, Krafty R, Capewell L, Boston R. Risk factors for development of acute laminitis in horses during hospitalization: 73 cases (1997–2004). J Am Vet Med Assoc. 2007;230:885–889
  20. Vick MM, Adams AA, Murphy BA, et al. Relationships among inflammatory cytokines, obesity, and insulin sensitivity in the horse. J Anim Sci. 2007;85:1144–1155
  21. Delesalle C, van de Walle GR, Nolten C, Ver Donck L, van Hemelrijck A, Drinkenburg W, et al. Determination of the source of increased serotonin (5-HT) concentrations in blood and peritoneal fluid of colic horses with compromised bowel. Equine Vet J. 2008;40:326–331
  22. Eades SC, Fugler LA, Riggs L. Controlling the equine neutrophil: a generator of devastating tissue damage during equine inflammatory disease. Vet J. 2008;178:3–4
  23. Budak M, Orsini JA, Rubinstein NA, Pollitt CC. Gene expression in the lamellar dermis-epidermis during the developmental phase of carbohydrate overload-induced laminitis in the horse. Vet Pathol Immunol. 2008;
  24. French KR, Pollitt CC. Equine laminitis: glucose deprivation and MMP activation induce dermo-epidermal separation in vitro. Equine Vet J. 2004;36:261–266
  25. Doucet MY, Bertone AL, Hendrickson D, Hughes F, Macallister C, McClure S, et al. Comparison of efficacy and safety of paste formulations of firocoxib and phenylbutazone in horses with naturally occurring osteoarthritis. J Am Vet Med Assoc. 2008;232:91–97
  26. Little D, Brown A, Campbell NB, Moeser AJ, Davis JL, Blikslager AT. Effects of the cyclooxygenase inhibitor meloxicam on recovery of ischemia-injured equine jejunum. Am J Vet Res. 2007;68:614–624
  27. de la Rebiere G, Franck T, Deby-Dupont G, Salciccia A, Grulke S, Péters F, et al. Effects of unfractionated and fractionated heparins on myeloperoxidase activity and interactions with endothelial cells: Possible effects on the pathophysiology of equine laminitis. Vet Journal. 2008;178:62–69
  28. Franck T, Kohnen S, Grulke S, Neven P, Goutman Y, Peters F, et al. Inhibitory effect of curcuminoids and tetrahydrocurcuminoids on equine activated neutrophils and myeloperoxidase activity. Physiol Res. 2008;57:577–587
  29. Larkins N, Wynn S. Pharmacognosy: phytomedicines and their mechanisms. Vet Clin North Am Small Animal Pract. 2004;34:291–327
  30. Jones E, Vinuela-Fernandez I, Eager RA, Delaney A, Anderson H, Patel A, et al. Neuropathic changes in equine laminitis pain. Pain. 2007;132:321–331
  31. Milinovich GJ, Burrell PC, Pollitt CC, Klieve AV, Blackall LL, Ouwerkerk D, et al. Microbial ecology of the equine hindgut during oligofructose-induced laminitis. The ISME J. 2008;2:1089–1100
  32. Krueger AS, Kinden DA, Garner HE, Sprouse RF. Ultrastructural study of the equine cecum during onset of laminitis. Am J Vet Res. 1986;47:1804–1812
  33. Weiss DJ, Evanson OA, MacLeay J, Brown DR. Transient alteration in intestinal permeability to technetium Tc99m diethylenetriaminopentaacetate during the prodromal stages of alimentary laminitis in ponies. Am J Vet Res. 1998;59:1431–1434
  34. Freestone JF, Beadle R, Shoemaker K, Bessin RT, Wolfsheimer KJ, Church C. Improved insulin sensitivity in hyperinsulinaemic ponies through physical conditioning and controlled feed intake. Equine Vet J. 1992;24:187–190
  35. Pratt SE, Geor RJ, McCutcheon LJ. Effects of dietary energy source and physical conditioning on insulin sensitivity and glucose tolerance in Standardbred horses. Equine Vet J. 2006;36(Suppl.):579–584
  36. Stewart-Hunt L, Geor RJ, McCutcheon LJ. Effects of short-term training on insulin sensitivity and skeletal muscle glucose metabolism in Standardbred horses. Equine Vet J. 2006;36(Suppl.):226–232
  37. Firshman AM, Valberg SJ. Factors affecting clinical assessment of insulin sensitivity in horses. Equine Vet J. 2007;39:567–575
  38. Durham AE, Rendle DI, Newton JE. The effect of metformin on measurements of insulin sensitivity and beta cell response in 18 horses and ponies with insulin resistance. Equine Vet J. 2008;40:493–500
  39. Nourian AR, Baldwin GI, van Eps AW, Pollitt CC. Equine laminitis: ultrastructural lesions detected 24–30 hours after induction with oligofructose. Equine Vet J. 2007;39:360–364
  40. Weiss DJ, Evanson OA, McClenahan D, Fagliari JJ, Dunnwiddie CT, Wells RE. Effect of a competitive inhibitor of platelet aggregation on experimentally induced laminitis in ponies. Am J Vet Res. 1998;59:814–817
  41. Bailey SR, Habershon-Butcher JL, Ransom KJ, Elliott J, Menzies-Gow NJ. Hypertension and insulin resistance in a mixed-breed population of ponies predisposed to laminitis. Am J Vet Res. 2008;69:122–129
  42. Toth F, Frank N, Elliott SB, Geor RJ, Boston RC. Effects of an intravenous endotoxin challenge on glucose and insulin dynamics in horses. Am J Vet Res. 2008;69:82–88
  43. Johnson PJ, Messer NT, Slight SH, Wiedmeyer C, Buff P, Ganjam VK. Endocrinopathic laminitis in the horse. Clin Techn Equine Pract. 2004;3:45–56
  44. Tiley HA, Geor RJ, McCutcheon LJ. Effects of dexamethasone on glucose dynamics and insulin sensitivity in healthy horses. Am J Vet Res. 2007;68:753–759
  45. Haffner JC, Eiler H, Hoffman RM, et al. Effect of a single dose of dexamethasone on glucose homeostasis in healthy horses using the combined intravenous glucose and insulin test. J Anim Sci. 2008;9:[E-pub ahead of print]

 Refereed

PII: S0737-0806(08)00435-8

doi: 10.1016/j.jevs.2008.12.009

Journal of Equine Veterinary Science
Volume 29, Issue 2 , Pages 105-114 , February 2009

Article Tools

* Image Usage & Resolution