Journal of Equine Veterinary Science
Volume 29, Issue 2 , Pages 87-94 , February 2009

Correlation of Plasma Insulin Concentration with Laminitis Score in a Field Study of Equine Cushing's Disease and Equine Metabolic Syndrome

  • Donald M. Walsh, DVM

      Affiliations

    • Homestead Veterinary Hospital, Pacific, MO
    • ,
  • Catherine M. McGowan, BVSc, PhD

      Affiliations

    • Department of Clinical Veterinary Science, University of Liverpool, Liverpool, UK
    • ,
  • Thomas McGowan, BSc, DVM

      Affiliations

    • School of Animal Studies, The University of Queensland, Brisbane, Australia
    • ,
  • Stephen V. Lamb, BS

      Affiliations

    • Department of Population Medicine & Diagnostic Sciences, Cornell University, Ithaca, NY
    • ,
  • Barbara J. Schanbacher, DVM

      Affiliations

    • Department of Population Medicine & Diagnostic Sciences, Cornell University, Ithaca, NY
    • ,
  • Ned J. Place, PhD, MD

      Affiliations

    • Department of Population Medicine & Diagnostic Sciences, Cornell University, Ithaca, NY
    • Corresponding Author InformationReprint requests: Ned J. Place, PhD, MD, Schurman Hall—S1-088, Department of Population Medicine & Diagnostic Sciences, Cornell University, Ithaca, NY 14853.

References 

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  2. Couëtil L, Paradis MR, Knoll J. Plasma adrenocorticotropin concentration in healthy horses and in horses with clinical signs of hyperadrenocorticism. J Vet Intern Med. 1996;10:1–6
  3. McGowan TW, McGowan CM. Sensitivity and specificity of basal endocrine tests in the diagnosis of equine Cushing's syndrome. Proceedings British Equine Veterinary Association; 2008 (Abstr.).
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  6. Perkins GA, Lamb S, Erb HN, Schanbacher B, Nydam DV, Divers TJ. Plasma adrenocorticotropin (ACTH) concentrations and clinical response in horses treated for equine Cushing's disease with cyproheptadine or pergolide. Equine Vet J. 2002;34:679–685
  7. Johnson PJ. The equine metabolic syndrome peripheral Cushing's syndrome. Vet Clin North Am Equine Pract. 2002;18:271–293
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  9. Reeves HJ, Lees R, McGowan CM. Measurement of basal serum insulin concentration in the diagnosis of Cushing's disease in ponies. Vet Rec. 2001;149:449–452
  10. Asplin KE, Sillence MN, Pollitt CC, McGowan CM. Induction of laminitis by prolonged hyperinsulinaemia in clinically normal ponies. Vet J. 2007;174:530–535
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  13. Carter RA, Geor RJ, Burton Staniar W, Cubitt TA, Harris PA. Apparent adiposity assessed by standardised scoring systems and morphometric measurements in horses and ponies. Vet J 2008;Apr 25 [Epub ahead of print].
  14. Obel N. Studies on the histopathology of acute laminitis [dissertation]. Uppsala: Almqvist & Wiksells Boltryckeri; 1948;AB
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  16. Reimers TJ, Cowan RG, McCann JP, Ross MW. Validation of a rapid solid-phase radioimmunoassay for canine, bovine, and equine insulin. Am J Vet Res. 1982;43:1274–1278
  17. Reimers TJ, Lamb SV, Bartlett SA, Matamoros RA, Cowan RG, Engle JS. Effects of hemolysis and storage on quantification of hormones in blood samples from dogs, cattle, and horses. Am J Vet Res. 1991;52:1075–1080
  18. Treiber KH, Kronfeld DS, Hess TM, Byrd BM, Splan RK. Pre-laminitic metabolic syndrome in genetically predisposed ponies involves compensated insulin resistance. J Anim Physiol Anim Nutr. 2005;89:430–431
  19. Jeffcott LB, Field JR, McLean JG, O'Dea K. Glucose tolerance and insulin sensitivity in ponies and Standardbred horses. Equine Vet J. 1986;18:97–101
  20. Treiber KH, Kronfeld DS, Geor RJ. Insulin resistance in equids; possible role in laminitis. J Nutr. 2006;136:2094S–2098S
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  22. Johnson PJ, Messer NT, Slight SH, Wiedmeyer C, Buff P, Ganjam VK. Endocrinopathic laminitis in the horse. Clin Tech Equine Pract. 2004;3:45–56
  23. Frank N. 2006. Insulin resistance in horses. In: Proceedings 52nd Annual Convention American Association of Equine Practitioners. Ithaca: International Veterinary Information Service (www.ivis.org), 2006; Document No. P5306.1206.
  24. Cline GW, Petersen KF, Krssak M, Shen J, Hundal RS, Trajanoski Z, et al. Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes. N Engl J Med. 1999;341:240–246
  25. Pass MA, Pollitt S, Pollitt CC. Decreased glucose metabolism causes separation of hoof lamellae in vitro: a trigger for laminitis?. Equine Vet J. 1998;26(Suppl.):133–138
  26. Asplin KE, McGowan CM, Pollitt CC, Curlewis J, Sillence MN. Role of insulin in glucose uptake in the equine hoof. J Vet Intern Med. 2007;21:668;(Abstr. 349)
  27. Poitout V, Robertson RP. Minireview: secondary β-cell failure in type 2 diabetes—a convergence of glucotoxicity and lipotoxicity. Endocrinology. 2002;143:339–342
  28. Frank N, Sommardahl CS, Eiler H, Webb LL, Denhart JW, Boston RC. Effects of oral administration of levothyroxine sodium on concentrations of plasma lipids, concentration and composition of very-low-density lipoproteins, and glucose dynamics in healthy adult mares. Am J Vet Res. 2005;66:1032–1038
  29. Frank N. Management of equine metabolic syndrome. In: Proceedings American College of Veterinary Internal Medicine Forum; 2007.
  30. Kronfeld DS, Treiber KH, Geor RJ. Comparison of nonspecific indications and quantitative methods for the assessment of insulin resistance in horses and ponies. J Am Vet Med Assoc. 2005;226:712–719

 Refereed

PII: S0737-0806(08)00432-2

doi: 10.1016/j.jevs.2008.12.006

Journal of Equine Veterinary Science
Volume 29, Issue 2 , Pages 87-94 , February 2009

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