Journal of Equine Veterinary Science
Volume 29, Issue 1 , Pages 33-36 , January 2009

Evaluation of Injectable Sustained Release Progestin Formulations for Suppression of Estrus and Ovulation in Mares

  • William A. Storer

      Affiliations

    • School of Animal Sciences, Louisiana Agriculture Experiment Station, LSU Agricultural Center, Baton Rouge, LA
    • ,
  • Donald L. Thompson Jr.

      Affiliations

    • School of Animal Sciences, Louisiana Agriculture Experiment Station, LSU Agricultural Center, Baton Rouge, LA
    • Corresponding Author InformationReprint requests: D. L. Thompson, Jr., School of Animal Sciences, Louisiana State University, Baton Rouge, LA 70803.
    • ,
  • Richard M. Gilley

      Affiliations

    • BioRelease Technologies LLC, Birmingham, AL
    • BET Pharm LLC, Lexington, KY
    • ,
  • Patrick J. Burns

      Affiliations

    • BioRelease Technologies LLC, Birmingham, AL
    • BET Pharm LLC, Lexington, KY
    • Burns BioSolutions Inc., Lexington, KY

References 

  1. Van Niekerk CH, Cobrough RI, Doms HWH. Progesterone treatment of mares with abnormal oestrous cycles early in the breeding season. J S Afr Vet Med Assoc. 1973;44:37–45
  2. Webel SK, Squires EL. Control of the oestrous cycle in mares with altrenogest. J Reprod Fert (Suppl). 1982;32:193–198
  3. Squires EL, Heesemann CP, Webel S, Shideler RK, Voss JL. Relationship of altrenogest to ovarian activity, hormone concentrations and fertility of mares. J Anim Sci. 1983;56:901–910
  4. Daels PF, McCue PM, Demoraes MJ, Hughes JP. Persistence of the luteal phase following ovulation during altrenogest treatment in mares. Theriogenology. 1996;46:799–811
  5. McKinnon AO, Lescun TB, Walker JH, Vasey JR, Allen WR. The inability of some synthetic progestagens to maintain pregnancy in the mare. Equine Vet J. 2000;32:83–85
  6. McKinnon AO, Tarrida del Marmol Figueroa S, Nobelius AM, Hyland JH, Vasey JR. Failure of hydroxyprogesterone caproate to maintain pregnancy in ovariectomised mares. Equine Vet J. 1993;25:158–160
  7. Squires EL, Martin JM, Jasko DJ. Reproductive response of mares after treatment with progestogens with and without the addition of estradiol. J Equine Vet Sci. 1992;12:28–32
  8. Burns PJ, Steiner JV, Sertich PL, Pozar M, Tice TR, Mason D, et al. Evaluation of biodegradable microspheres for the controlled release of progesterone and estradiol in an ovulation control program for cycling mares. J Equine Vet Sci. 1993;13:521–524
  9. Blanchard TL, Varner DD, Burns PJ, Everett KA, Brinsko SP, Boehnke L. Regulation of estrus and ovulation in cyclic mares with progesterone or progesterone and estradiol biodegradable microspheres with or without PGF-2α. Theriogenology. 1992;38:1091–1106
  10. Henneke DR, Potter GD, Kreider JL, Yeates BF. Relationship between condition score, physical measurements and body fat percentage in mares. Equine Vet J. 1983;15:371–376
  11. Thompson DL, Godke RA, Squires EL. Testosterone effects on mares during synchronization with altrenogest: FSH, LH, estrous duration and pregnancy rate. J Anim Sci. 1983;56:678–686
  12. McKinnon AO, Squires EL, Carnevale EM, Hermenet MJ. Ovariectomized steroid-treated mares as embryo transfer recipients and as a model to study the role of progestins in pregnancy maintenance. Theriogenology. 1988;29:1055–1063
  13. Squires EL. Progestin. In:  McKinnon AO,  Voss JL editor. Equine reproduction. Media, PA: Williams & Wilkins; 1993;p. 311–318

 Approved for publication by the Director of the Louisiana Agric. Exp. Sta. as manuscript no. 2008-230-1610.

 Refereed

PII: S0737-0806(08)00378-X

doi: 10.1016/j.jevs.2008.11.007

Journal of Equine Veterinary Science
Volume 29, Issue 1 , Pages 33-36 , January 2009

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