Journal of Equine Veterinary Science
Volume 29, Issue 1 , Pages 37-41, January 2009

Polymorphism Analysis of Microsatellites Associated with Seven Candidate Genes for Equine Cryptorchidism

  • Mathieu Diribarne

      Affiliations

    • INRA, CRJ, UR 339 Laboratoire de Génétique biochimique et Cytogénétique, 78350 Jouy-en-Josas, France
    • ,
  • Anne Vaiman

      Affiliations

    • INRA, CRJ, UR 339 Laboratoire de Génétique biochimique et Cytogénétique, 78350 Jouy-en-Josas, France
    • ,
  • Michel Péchayre

      Affiliations

    • Clinique vétérinaire des Aigles, Lamorlaye, France
    • ,
  • E. Pailhoux

      Affiliations

    • INRA, CRJ, UMR 1198 Biologie du Développement et Reproduction, 78350 Jouy-en-Josas, France
    • ,
  • Xavier Mata

      Affiliations

    • INRA, CRJ, UR 339 Laboratoire de Génétique biochimique et Cytogénétique, 78350 Jouy-en-Josas, France
    • ,
  • Gérard Guérin

      Affiliations

    • INRA, CRJ, UR 339 Laboratoire de Génétique biochimique et Cytogénétique, 78350 Jouy-en-Josas, France
    • ,
  • Stéphane Chaffaux

      Affiliations

    • INRA, CRJ, UR 339 Laboratoire de Génétique biochimique et Cytogénétique, 78350 Jouy-en-Josas, France
    • Corresponding Author InformationReprint requests: Stéphane Chaffaux, INRA, CRJ, UR 339 Laboratoire de Genetique biochimique et Cytogénétique.

Abstract 

Association of seven candidate genes with cryptorchidism was investigated in the Thoroughbred. A pedigree composed of 23 cryptorchids and 24 nonaffected horses, sharing a common ancestor, was constituted. Sixteen microsatellite markers were developed either from bacterial artificial chromosomes (BAC) isolated for each candidate gene or by in silico screening. DNA from our pedigree was genotyped for these microsatellites. Statistical analysis of the allelic and genotypic frequencies observed with these markers did not reveal any association between the candidate genes and the cryptorchidism phenotype in our horse panel.

Keywords: Cryptorchidism, Thoroughbred, Candidate genes, Microsatellite, Association analysis

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 Refereed

PII: S0737-0806(08)00374-2

doi:10.1016/j.jevs.2008.11.003

Journal of Equine Veterinary Science
Volume 29, Issue 1 , Pages 37-41, January 2009

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