Journal of Equine Veterinary Science
Volume 28, Issue 12 , Pages 739-742 , December 2008

Topical Dexamethasone and Dimethyl Sulfoxide Solutions Do Not Result in Detectable Blood Levels of Dexamethasone

  • Janice Sojka, VMD, MS, DACVIM

      Affiliations

    • Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, IN
    • Corresponding Author InformationReprint requests: Janice Sojka, VMD, MS, DACVIM, Department VCS, Purdue University, West Lafayette, IN 47907.
    • ,
  • Ursula Jedra, DVM

      Affiliations

    • Indiana Racing Commission, Indianapolis, IN
    • ,
  • Norman Hester, PhD

      Affiliations

    • Truesdail Laboratories, Tustin CA
    • ,
  • L. Paige Jackson, DVM

      Affiliations

    • Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, IN
    • ,
  • A. Juarez, BS

      Affiliations

    • Truesdail Laboratories, Tustin CA

References 

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  2. Cohen ND, Mundy GD, Peloso JG, Carey VJ, Amend NK. Results of physical inspection before races and race-related characteristics and their association with musculoskeletal injuries in Thoroughbreds during races. J Am Vet Med Assoc. 1999;215:654–661
  3. Ho EN, Leung DK, Wan TS, Yu NH. Comprehensive screening of anabolic steroids, corticosteroids, and acidic drugs in horse urine by solid-phase extraction and liquid chromatography. Chromatography A. 2006;1120:38–53
  4. Alsup EM, DeBowes RM. Dimethyl sulfoxide. J Am Vet Med Assoc. 1984;185:1011–1014
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  12. Hayes RC. Adrenocorticotropic hormone: adrenocortical steroid and the synthetic analogs: inhibitors of the synthesis and action of adrenocortical hormones. In:  Gilman AG,  Rall TW,  Nies AS,  Tayler P editor. Goodman and Gilman's:The Pharmacological Basis of Therapeutics. 8th ed.. New York: Pergamon Press; 1990;p. 1442–1447
  13. Soma LR, Uboh CE, Luo Y, Guan F, Moate PJ, Boston RC. Pharmacokinetics of dexamethasone with pharmacokinetic/pharmacodynamic model of the effect of dexamethasone on endogenous hydrocortisone and cortisone in the horse. J Vet Pharmacol Ther. 2005;28:71–80
  14. Luo Y, Uboh CE, Soma LH, Guan F, Rudy JA, Tsang DS. Resolution, and quantification and confirmation of betamethasone and dexamethasone in equine plasma by liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom. 2005;19:825–832
  15. Spiess BM, Nyikos S, Stummer E, Sahin A, Naegeli H. Systemic dexamethasone concentration in horses after continued topical treatment with an ophthalmic preparation of dexamethasone. Am J Vet Res. 1999;60:571–576
  16. Rush BR, Raub ES, Thomsen MM, Davis EG, Matson CJ, Hakala JE. Pulmonary function and adrenal gland suppression with incremental doses of aerosolized beclomethasone dipropionate in horses with recurrent airway obstruction. J Am Vet Med Assoc. 2000;217:359–364
  17. Soma LR, Uboh CE, Luo Y, Guan F, Moate PJ, Boston RC. Pharmacokinetics of methylprednisolone acetate after intra-articular administration and its effect on endogenous hydrocortisone and cortisone secretion in horses. Am J Vet Res. 2006;67:654–662
  18. Smith G, Bertone AL, Kaeding C, Simmons EJ, Apostoles S. Anti-inflammatory effects of topically applied dimethyl sulfoxide gel on endotoxin-induced synovitis in horses. Am J Vet Res. 1998;59:1149–1152
  19. Schuh JC, Ross C, Meschter C. Concurrent mercuric blister and dimethyl sulfoxide (DMSO) application as a cause of mercury toxicity in two horses. Equine Vet J. 1988;20:68–71

 Refereed

PII: S0737-0806(08)00351-1

doi: 10.1016/j.jevs.2008.10.021

Journal of Equine Veterinary Science
Volume 28, Issue 12 , Pages 739-742 , December 2008

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