Journal of Equine Veterinary Science
Volume 28, Issue 11 , Pages 645-649 , November 2008

Genetic Testing and the Future of Equine Genomics

  • Danika Bannasch, DVM, PhD

      Affiliations

    • Corresponding Author InformationReprint requests: Danika Bannasch, DVM PhD, Department of Population Health and Reproduction School of Veterinary Medicine, University of California, Davis, Davis, CA 95616.

References 

  1. Rudolph JA, Spier SJ, Byrns G, Rojas CV, Bernoco D, Hoffman EP. Periodic paralysis in quarter horses: a sodium channel mutation disseminated by selective breeding. Nat Genet. 1992;2:144–147
  2. Naylor JM, Nickel DD, Trimino G, Card C, Lightfoot K, Adams G. Hyperkalaemic periodic paralysis in homozygous and heterozygous horses: a co-dominant genetic condition. Equine Vet J. 1999;31:153–159
  3. Shin EK, Perryman LE, Meek K. A kinase-negative mutation of DNA-PK(CS) in equine SCID results in defective coding and signal joint formation. J Immunol. 1997;158:3565–3569
  4. Metallinos DL, Bowling AT, Rine J. A missense mutation in the endothelin-B receptor gene is associated with Lethal White Foal Syndrome: an equine version of Hirschsprung disease. Mamm Genome. 1998;9:426–431
  5. Santschi EM, Purdy AK, Valberg SJ, Vrotsos PD, Kaese H, Mickelson JR. Endothelin receptor B polymorphism associated with lethal white foal syndrome in horses. Mamm Genome. 1998;9:306–309
  6. Yang GC, Croaker D, Zhang AL, Manglick P, Cartmill T, Cass D. A dinucleotide mutation in the endothelin-B receptor gene is associated with lethal white foal syndrome (LWFS); a horse variant of Hirschsprung disease. Hum Mol Genet. 1998;7:1047–1052
  7. Spirito F, Charlesworth A, Linder K, Ortonne JP, Baird J, Meneguzzi G. Animal models for skin blistering conditions: absence of laminin 5 causes hereditary junctional mechanobullous disease in the Belgian horse. J Invest Dermatol. 2002;119:684–691
  8. Marklund L, Moller MJ, Sandberg K, Andersson L. A missense mutation in the gene for melanocyte-stimulating hormone receptor (MC1R) is associated with the chestnut coat color in horses. Mamm Genome. 1996;7:895–899
  9. Rieder S, Taourit S, Mariat D, Langlois B, Guerin G. Mutations in the agouti (ASIP), the extension (MC1R), and the brown (TYRP1) loci and their association to coat color phenotypes in horses (Equus caballus). Mamm Genome. 2001;12:450–455
  10. Haase B, Brooks SA, Schlumbaum A, Azor PJ, Bailey E, Alaeddine F, et al. Allelic heterogeneity at the equine KIT locus in dominant white (W) horses. PLoS Genet. 2007;3:e195
  11. Brooks SA, Bailey E. Exon skipping in the KIT gene causes a Sabino spotting pattern in horses. Mamm Genome. 2005;16:893–902
  12. Brunberg E, Andersson L, Cothran G, Sandberg K, Mikko S, Lindgren G. A missense mutation in PMEL17 is associated with the Silver coat color in the horse. BMC Genet. 2006;7:46
  13. Trommershausen-Smith A. Linkage of tobiano coat spotting and albumin markers in a pony family. J Hered. 1978;69:214–216
  14. Brooks SA, Lear TL, Adelson DL, Bailey E. A chromosome inversion near the KIT gene and the Tobiano spotting pattern in horses. Cytogenet Genome Res. 2007;119:225–230
  15. Locke MM, Ruth LS, Millon LV, Penedo MC, Murray JD, Bowling AT. The cream dilution gene, responsible for the palomino and buckskin coat colours, maps to horse chromosome 21. Anim Genet. 2001;32:340–343
  16. Mariat D, Taourit S, Guerin G. A mutation in the MATP gene causes the cream coat colour in the horse. Genet Sel Evol. 2003;35:119–133
  17. Locke MM, Penedo MC, Bricker SJ, Millon LV, Murray JD. Linkage of the grey coat colour locus to microsatellites on horse chromosome 25. Anim Genet. 2002;33:329–337
  18. Pielberg G, Mikko S, Sandberg K, Andersson L. Comparative linkage mapping of the Grey coat colour gene in horses. Anim Genet. 2005;36:390–395
  19. Swinburne JE, Hopkins A, Binns MM. Assignment of the horse grey coat colour gene to ECA25 using whole genome scanning. Anim Genet. 2002;33:338–342
  20. Bellone RR, Brooks SA, Sandmeyer L, Murphy BA, Forsyth G, Archer S, et al. Differential gene expression of TRPM1, the potential cause of congenital stationary night blindness (CSNB) and coat spotting patterns (LP) in the Appaloosa horse (Equus caballus). Genetics. 2008;
  21. Terry RB, Archer S, Brooks S, Bernoco D, Bailey E. Assignment of the appaloosa coat colour gene (LP) to equine chromosome 1. Anim Genet. 2004;35:134–137
  22. Rosengren Pielberg G, Golovko A, Sundstrom E, Curik I, Lennartsson J, Seltenhammer MH, et al. A cis-acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horse. Nat Genet. 2008;40:1004–1009
  23. Metallinos DL. Canine molecular genetic testing. Vet Clin North Am: Small Anim Pract. 2001;31:421–431
  24. Tryon RC, White SD, Bannasch DL. Homozygosity mapping approach identifies a missense mutation in equine cyclophilin B (PPIB) associated with HERDA in the American Quarter Horse. Genomics. 2007;90:93–102
  25. McCue ME, Valberg SJ, Miller MB, Wade C, DiMauro S, Akman HO, et al. Glycogen synthase (GYS1) mutation causes a novel skeletal muscle glycogenosis. Genomics. 2008;91:458–466
  26. Wade C, Gnerre S, Garber M, BIGSaA Team, Lander E, Lindblad-Toh K, et al. Preliminary analysis of the equine genome sequence. Plant and Animal Genome Conference XVI. 2008;
  27. Karlsson EK, Baranowska I, Wade CM, Salmon Hillbertz NH, Zody MC, Anderson N, et al. Efficient mapping of mendelian traits in dogs through genome-wide association. Nat Genet. 2007;39:1321–1328
  28. Smith B. Large Animal Internal Medicine. Mosby Elsevier: St Louis; 2008;
  29. Seltenhammer MH, Simhofer H, Scherzer S, Zechner R, Curik I, Solkner J, et al. Equine melanoma in a population of 296 grey Lipizzaner horses. Equine Vet J. 2003;35:153–157

 Refereed

PII: S0737-0806(08)00334-1

doi: 10.1016/j.jevs.2008.10.004

Journal of Equine Veterinary Science
Volume 28, Issue 11 , Pages 645-649 , November 2008

Article Tools