Journal of Equine Veterinary Science
Volume 28, Issue 10 , Pages 579-586 , October 2008

Hyperleptinemia in Mares: Prevalence in Lactating Mares and Effect on Rebreeding Success

References 

  1. Selk GE, Wettemann RP, Lusby KS, Oltjen JW, Mobley SL, Rasby RJ, et al. Relationship among weight change, body condition and reproductive performance of range beef cows. J Anim Sci. 1988;66:3153–3159
  2. Schillo KK, Hall JB, Hileman SM. Effect of nutrition and season on the onset of puberty in the beef heifer. J Anim Sci. 1992;70:3994–4005
  3. Henneke DR, Potter GD, Kreider JL. Body condition during pregnancy and lactation and reproductive efficiency of mares. Theriogenology. 1984;21:897–909
  4. Gentry LR, Thompson DL, Gentry GT, Davis KA, Godke RA, Cartmill JA. The relationship between body condition, leptin, and reproductive and hormonal characteristics of mares during the seasonal anovulatory period. J Anim Sci. 2002;80:2695–2703
  5. Heidler B, Aurich JE, Pohl W, Aurich C. Body weight of mares and foals, estrous cycles and plasma glucose concentration in lactating and non-lactating Lipizzaner mares. Theriogenology. 2004;61:883–893
  6. Heidler B, Parvizi N, Sauerwein H, Bruckmaier RM, Heintges U, Aurich JE, et al. Effects of lactation on metabolic and reproductive hormones in Lipizzaner mares. Dom Anim Endocrinol. 2003;25:47–59
  7. Johnson PJ. The equine metabolic syndrome: Peripheral Cushing's syndrome. Vet Clin North Am Equine Pract. 2002;18:271–293
  8. Firshman AM, Valberg SJ. Factors affecting clinical assessment of insulin sensitivity in horses. Equine Vet J. 2007;39:567–575
  9. Vick MM, Adams AA, Murphy BA, Sessions DR, Horohov DW, Cook RF, et al. Relationships among inflammatory cytokines, obesity, and insulin sensitivity in the horse. J Anim Sci. 2007;85:1144–1155
  10. Cartmill JA, Thompson DL, Storer WA, Gentry LR, Huff NK. Endocrine responses in mares and geldings with high body condition scores grouped by high vs low resting leptin concentrations. J Anim Sci. 2003;81:2311–2321
  11. Fitzgerald BP, McManus CJ. Photoperiodic versus metabolic signals as determinants of seasonal anestrus in the mare. Biol Reprod. 2000;63:335–340
  12. Waller CA, Thompson DL, Cartmill JA, Storer WA, Huff NK. Reproduction in high body condition mares with high versus low leptin concentrations. Theriogenology. 2005;66:923–928
  13. Mantzoros CS, Cramer DW, Liberman RF, Barbieri RL. Predictive value of serum and follicular fluid leptin concentrations during assisted reproductive cycles in normal women and in women with the polycystic ovarian syndrome. Hum Reprod. 2000;15:539–544
  14. Spicer LJ, Francisco CC. Adipose obese gene product, leptin, inhibits bovine ovarian thecal cell steroidogenesis. Biol Reprod. 1998;58:207–212
  15. Spicer LJ. Leptin: a possible metabolic signal affecting reproduction. Dom Anim Endocrinol. 2001;21:251–270
  16. Greisen S, Ledet T, Moller N, Jorgensen JO, Christiansen JS, Petersen K, et al. Effects of leptin on basal and FSH stimulated steroidogenesis in human granulosa luteal cells. Acta Ob Gyn Scand. 2000;79:931–935
  17. Henneke DR, Potter GD, Kreider JL, Yeates BF. Relationship between condition score, physical measurements and body fat percentage in mares. Equine Vet J. 1983;15:371–376
  18. Cartmill JA, Thompson DL, Storer WA, Crowley JC, Huff NK, Waller CA. Effect of dexamethasone, feeding time, and insulin infusion on leptin concentrations in stallions. J Anim Sci. 2005;83:1875–1881
  19. Kronfeld DS, Treiber KH, Hess TM, Splan RK, Byrd BM, Staniar WB, et al. Metabolic syndrome in healthy ponies facilitates nutritional countermeasures against pasture laminitis. J Nutr. 2006;136(Suppl 7):2090S–2093S
  20. Buff PR, Morrison CD, Ganjam VK, Keisler DH. Effects of short-term feed deprivation and melatonin implants on circadian patterns of leptin in the horse. J Anim Sci. 2005;83:1023–1032
  21. Steelman SM, Michael-Eller EM, Gibbs PG, Potter GD. Meal size and feeding frequency influence serum leptin concentration in yearling horses. J Anim Sci. 2006;84:2391–2398
  22. Storer WA, Thompson DL, Waller CA, Cartmill JA. Hormonal patterns in normal and hyperleptinemic mares in response to three common feeding-housing regimens. J Anim Sci. 2007;85:2873–2881
  23. Ferreira-Dias G, Claudino F, Carvalho H, Agricola R, Alpoim-Moreira J, Silva JR. Seasonal reproduction in the mare: Possible role of plasma leptin, body weight, and immune status. Dom Anim Endocrinol. 2005;29:203–213
  24. Kearns CF, McKeever KH, Roegner V, Brady SM, Malinowski K. Adiponectin and leptin are related to fat mass in horses. Vet J. 2006;172:460–465
  25. Buff PR, Dodds AC, Morrison CD, Whitley NC, McFadin EL, Daniel JA, et al. Leptin in horses: tissue localization and relationship between peripheral concentrations of leptin and body condition. J Anim Sci. 2002;80:2942–2948
  26. Savio JD, Boland MP, Hynes N, Roche JF. Resumption of follicular activity in the early postpartum period of dairy cows. J Reprod Fertil. 1990;88:569–579
  27. Jolly PD, McDougall S, Fitzpatrick LA, Macmillan KA, Entwistle KW, Scaramuzzi RJ. Physiological effect of undernutrition on postpartum anoestrus in cows. J Reprod Fertil (Suppl). 1995;49:477–492
  28. Ginther OJ. Reproductive biology of the mare-basic and applied aspects. Cross Plains, WI: Equiservices. 1993;
  29. Bain AM, Howey WP. Observations on the time of foaling in Thoroughbred mares in Australia. J Reprod Fertil. 1975;(Suppl 23):545–546
  30. Morris LHA, Allen WR. Reproductive efficiency of intensively managed Thoroughbred mares in Newmarket. Equine Vet J. 2002;34:51–60
  31. Merkt H, Günzel AR. A survey of early pregnancy losses in West German Thoroughbred mares. Equine Vet J. 1979;11:256–258
  32. Van Niekerk CH, Van Niekerk FE. The effect of dietary protein on reproduction in the mare. VII. Embryonic development, early embryonic death, fetal losses and their relationship with serum progestagen. J S Afr Vet Assoc. 1998;69:150–155
  33. Treiber KH, Kronfeld DS, Hess TM, Byrd BM, Splan RK, Staniar WB. Evaluation of genetic and metabolic predispositions and nutritional risk factors for pasture-associated laminitis in ponies. J Am Vet Med Assoc. 2006;228:1538–1545
  34. Spicer LJ, Francisco CC. The adipose obese gene product, leptin: evidence of a direct inhibitory role in ovarian function. Endocrinology. 1997;138:3374–3379
  35. Agarwal SK, Vogel K, Weitsman SR, Magoffin DA. Leptin antagonizes the insulin-like growth factor-I augmentation of steroidogenesis in granulosa and theca cells of the human ovary. J Clin Endocrinol Metab. 1999;84:1072–1076
  36. McManus CJ, Fitzgerald BP. Effects of a single day of feed restriction on changes in serum leptin, gonadotropins, prolactin and metabolites in aged and young mares. Dom Anim Endocrinol. 2000;19:1–13

 Approved for publication by the Director of the Louisiana Agric. Exp. Sta. as manuscript no. 2008-230-1561. We thank A. F. Parlow and the Natl. Inst. of Diabetes and Digestive and Kidney Diseases, National Hormone and Pituitary Program, Harbor-University of California Los Angeles Medical Center, Torrance, CA, and T. G. Ramsay, Growth Biology Laboratory, ARS, USDA, Beltsville, MD, for reagents.

 Refereed

PII: S0737-0806(08)00281-5

doi: 10.1016/j.jevs.2008.08.008

Journal of Equine Veterinary Science
Volume 28, Issue 10 , Pages 579-586 , October 2008

Article Tools

* Image Usage & Resolution