Journal of Equine Veterinary Science
Volume 28, Issue 8 , Pages 454-460 , August 2008

Dynamics of the Equine Preovulatory Follicle and Periovulatory Hormones: What's New?

  • O.J. Ginther, VMD, PhD

      Affiliations

    • Eutheria Foundation, Cross Plains, WI
    • Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI
    • Corresponding Author InformationReprint requests: O.J. Ginther, Department of Pathobiological Sciences, School of Veterinary Medicine, 1656 Linden Drive, University of Wisconsin, Madison, WI 53706.
  • ,
  • E.L. Gastal, DVM, PhD

      Affiliations

    • Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI
  • ,
  • M.O. Gastal, DVM, PhD

      Affiliations

    • Eutheria Foundation, Cross Plains, WI
  • ,
  • M.A. Beg, DVM, PhD

      Affiliations

    • Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI

References 

  1. Smith ID, Basset JM, Williams T. Progesterone concentrations in the peripheral plasma of the mare during the oestrous cycle. J Endocrinol. 1970;47:523–524
  2. Whitmore HL, Wentworth BC, Ginther OJ. Circulating concentrations of luteinizing hormone during estrous cycle of mares as determined by radioimmunoassay. Am J Vet Res. 1973;34:631–636
  3. Pattison ML, Chen CL, Kelley ST, Brandt GW. Luteinizing hormone and estradiol in peripheral blood of mares during estrous cycle. Biol Reprod. 1974;11:245–250
  4. Evans MJ, Irvine CHG. Serum concentrations of FSH, LH and progesterone during the estrous cycle and early pregnancy in the mare. J Reprod Fertil (Suppl). 1975;23:193–200
  5. Bergfelt DR, Mann BG, Schwartz NB, Ginther OJ. Circulating concentrations of immunoreactive inhibin and FSH during the estrous cycle of mares. J Equine Vet Sci. 1991;11:319–322
  6. Ginther OJ. Reproductive biology of the mare: basic and applied aspects. 2nd ed.. Cross Plains, WI: Equiservices Publishing; 1992;
  7. Ginther OJ, Beg MA, Gastal MO, Gastal EL. Follicle dynamics and selection in mares. Anim Reprod. 2004;1:45–63
  8. Ginther OJ. Selection of the dominant follicle in cattle and horses. Anim Reprod Sci. 2000;60–61:61–79
  9. Ginther OJ, Utt MD, Bergfelt DR, Beg MA. Controlling interrelationships of progesterone/LH and estradiol/LH in mares. Anim Reprod Sci. 2006;95:144–150
  10. Jacob JC, Gastal EL, Gastal MO, Carvalho GR, Beg MA, Ginther OJ. Temporal relationships and repeatability of follicle diameters and hormone concentrations within individual mares. Reprod Dom Anim. 2007;doi:10.111/j.1439-0531.2007.01003.x.
  11. Haughian JM, Ginther OJ, Kot K, Wiltbank MC. Relationships between FSH patterns and follicular dynamics and the temporal associations among hormones in natural and GnRH-induced gonadotropin surges in heifers. Reproduction. 2004;127:23–33
  12. Ginther OJ, Utt MD, Beg MA, Gastal EL, Gastal MO. Negative effect of estradiol on LH throughout the ovulatory LH surge in mares. Biol Reprod. 2007;77:543–550
  13. Ginther OJ, Gastal EL, Gastal MO, Beg MA. Regulation of circulating gonadotropins by the negative effects of ovarian hormones in mares. Biol Reprod. 2005;73:315–323
  14. Gastal EL, Gastal MO, Ginther OJ. Relationships of changes in B-mode echotexture and colour-Doppler signals in the wall of the preovulatory follicle to changes in systemic oestradiol concentrations and the effects of human chorionic gonadotrophin in mares. Reproduction. 2006;131:699–709
  15. Donadeu FX, Ginther OJ. Suppression of circulating concentrations of FSH and LH by inhibin and estradiol during the initiation of follicle deviation in mares. Theriogenology. 2003;60:1423–1434
  16. Donadeu FX, Ginther OJ. Effect of number and diameter of follicles on plasma concentrations of inhibin and FSH in mares. Reproduction. 2001;121:897–903
  17. Miller KF, Wesson JA, Ginther OJ. Interaction of estradiol and a nonsteroidal follicular fluid substance in the regulation of gonadotropin secretion in the mare. Biol Reprod. 1981;24:354–358
  18. Gastal EL, Bergfelt DR, Nogueira GP, Gastal MO, Ginther OJ. Role of luteinizing hormone in follicle deviation based on manipulating progesterone concentrations in mares. Biol Reprod. 1999;61:1492–1498
  19. Ginther OJ, Jacob JC, Gastal MO, Gastal EL, Beg MA. Development of one versus multiple ovulatory follicles and associated systemic hormone concentrations in mares. Reprod Dom Anim 2008 (in press). Doi 10.1111/j.1439-0531-2008.01109.x.
  20. Cuervo-Arango J, Newcombe JR. Repeatability of preovulatory diameter and uterine edema pattern in two consecutive cycles in the mare and how they are influenced by ovulation inductors. Theriogenology. 2008;69:681–687
  21. Gastal EL, Gastal MO, Ginther OJ. Serrated granulosa and other discrete ultrasound indicators of impending ovulation in mares. J Equine Vet Sci. 2006;26:67–72
  22. Ginther OJ, Gastal EL, Gastal MO, Bergfelt DR, Baerwald AR, Pierson RA. Comparative study of the dynamics of follicular waves in mares and women. Biol Reprod. 2004;71:1195–1201
  23. Ginther OJ, Gastal EL, Gastal MO, Beg MA. Passage of postovulatory follicular fluid into the peritoneal cavity and the effect on concentrations of circulating hormones in mares. Anim Reprod Sci. 2008;107:1–8
  24. Townson DH, Ginther OJ. Ultrasonic characterization of follicular evacuation during ovulation and the fate of the discharged follicular fluid in mares. Anim Reprod Sci. 1989;20:131–141
  25. Gastal EL, Jacob JCF, Gastal MO, Ginther OJ. Accumulation of fluid in the infundibulum during the estrous cycle in mares. J Equine Vet Sci. 2007;27:251–259
  26. Ginther OJ, Gastal EL, Gastal MO. Spatial relationships between serrated granulosa and vascularity of the preovulatory follicle and developing corpus luteum. J Equine Vet Sci. 2007;27:20–27
  27. Nambo Y, Hashimoto K, Nakai R, Asai Y, Watanabe G, Taya K. Biological significance of follicular fluid discharged into the peritoneal cavity at ovulation in mares. Anim Reprod Sci. 2006;94:228–231
  28. Ginther OJ, Gastal EL, Rodrigues BL, Gastal MO, Beg MA. Follicle diameters and hormone concentrations in the development of double versus single ovulations in mares. Theriogenology. 2007;69:583–590
  29. Jacob JC, Gastal EL, Gastal MO, Carvalho GR, Beg MA, Ginther OJ. Follicle deviation in ovulatory follicular waves with one or two dominant follicles in mares. Reprod Dom Anim. 2007;doi:10.111/j.1439-0531.2007.01048.x.

 Refereed

PII: S0737-0806(08)00211-6

doi: 10.1016/j.jevs.2008.07.008

Journal of Equine Veterinary Science
Volume 28, Issue 8 , Pages 454-460 , August 2008