Journal of Equine Veterinary Science
Volume 28, Issue 7 , Pages 431-436 , July 2008

Autosomic 27 Trisomy in a Standardbred Colt

  • Leonardo F.C. Brito, DVM, PhD

      Affiliations

    • Section of Reproduction, Department of Clinical Studies New Bolton Center, School of Veterinary Medicine, University of Pennsylvania
    • Corresponding Author InformationReprint requests: L.F.C Brito, DVM, PhD, ABS Global Inc., 1525 River Road, DeForest, WI 53532.
    • ,
  • Patricia L. Sertich, MS, VMD

      Affiliations

    • Section of Reproduction, Department of Clinical Studies New Bolton Center, School of Veterinary Medicine, University of Pennsylvania
    • ,
  • Keith Durkin, BSc

      Affiliations

    • Department of Veterinary Integrative Biosciences, College of Veterinary Medicine, Texas A&M University, College Station, TX
    • ,
  • Bhanu P. Chowdhary, BVSc&AH, PhD

      Affiliations

    • Department of Veterinary Integrative Biosciences, College of Veterinary Medicine, Texas A&M University, College Station, TX
    • ,
  • Regina M. Turner, VMD, PhD

      Affiliations

    • Section of Reproduction, Department of Clinical Studies New Bolton Center, School of Veterinary Medicine, University of Pennsylvania
    • ,
  • Lauren M. Greene, VMD

      Affiliations

    • Section of Reproduction, Department of Clinical Studies New Bolton Center, School of Veterinary Medicine, University of Pennsylvania
    • ,
  • Sue McDonnell, PhD

      Affiliations

    • Section of Reproduction, Department of Clinical Studies New Bolton Center, School of Veterinary Medicine, University of Pennsylvania

References 

  1. Griffin DK. The incidence, origin, and etiology of aneuploidy. Int Rev Cytol. 1996;167:263–296
  2. Pellestor F, Anahory T, Hamamah S. Effect of maternal age on the frequency of cytogenetic abnormalities in human oocytes. Cytogenet Genome Res. 2005;111:206–212
  3. Petersen MB, Mikkelsen M. Nondisjunction in trisomy 21: origin and mechanisms. Cytogenet Cell Genet. 2000;91:199–203
  4. Klunder LR, McFeely RA, Beech J, McClune W. Autosomal trisomy in a Standardbred colt. Equine Vet J. 1989;21:69–70
  5. Bowling AT, Millon LV. Two autosomal trisomies in the horse: 64,XX,-26,+t(26q26q) and 65,XX,+30. Genome. 1990;33:679–682
  6. Buoen LC, Zhang TQ, Weber AF, Turner T, Bellamy J, Ruth GR. Arthrogryposis in the foal and its possible relation to autosomal trisomy. Equine Vet J. 1997;29:60–62
  7. Power MM. Equine half sibs with an unbalanced X;15 translocation or trisomy 28. Cytogenet Cell Genet. 1987;45:163–168
  8. Lear TL, Cox JH, Kennedy GA. Autosomal trisomy in a Thoroughbred colt: 65,XY,+31. Equine Vet J. 1999;31:85–88
  9. Arrighi FE, Hsu TC. Localization of heterochromatin in human chromosomes. Cytogenetics. 1971;10:81–86
  10. Seabright M. The use of proteolytic enzymes for the mapping of structural rearrangements in the chromosomes of man. Chromosoma. 1972;36:204–210
  11. Bowling AT, Breen M, Chowdhary BP, Hirota K, Lear TL, Millon LV, et al. International system for cytogenetic nomenclature of the domestic horse: report of the Third International Committee for the Standardization of the domestic horse karyotype, Davis, CA, USA, 1996. Chromosome Res. 1997;5:433–443
  12. Perrocheau M, Boutreux V, Chadi S, Mata X, Decaunes P, Raudsepp T, et al. Construction of a medium-density horse gene map. Anim Genet. 2006;37:145–155
  13. Raudsepp T, Kijas J, Godard S, Guérin G, Andersson L, Chowdhary BP. Comparison of horse chromosome 3 with donkey and human chromosomes by cross-species painting and heterologous FISH mapping. Mamm Genome. 1999;10:277–282
  14. Chowdhary BP, Raudsepp T, Kata SR, Goh G, Millon LV, Allan V, et al. The first-generation whole-genome radiation hybrid map in the horse identifies conserved segments in human and mouse genomes. Genome Res. 2003;13:742–751
  15. Richer CL, Power MM, Klunder LR, McFeely RA, Kent MG. Standard karyotype of the domestic horse (Equus caballus): committee for standardized karyotype of Equus caballus. The Second International Conference for Standardization of Domestic Animal Karyotypes, INRA. Hereditas. 1990;112:289–293
  16. Hsu LY, Yu MT, Neu RL, Van Dyke DL, Benn PA, Bradshaw CL, et al. Rare trisomy mosaicism diagnosed in amniocytes, involving an autosome other than chromosomes 13, 18, 20, and 21: karyotype/phenotype correlations. Prenat Diagn. 1997;17:201–242
  17. Buwe A, Guttenbach M, Schmid M. Effect of paternal age on the frequency of cytogenetic abnormalities in human spermatozoa. Cytogenet Genome Res. 2005;111:213–228
  18. Parker AW, Bronks R, Snyder CW. Walking patterns in Down's syndrome. J Ment Defic Res. 1986;30(Pt 4):317–330
  19. Hampton TG, Stasko MR, Kale A, Amende I, Costa AC. Gait dynamics in trisomic mice: quantitative neurological traits of Down syndrome. Physiol Behav. 2004;82:381–389
  20. Amann RP, Veeramachaneni DN. Cryptorchidism in common eutherian mammals. Reproduction. 2007;133:541–561
  21. Chew G, Hutson JM. Incidence of cryptorchidism and ascending testes in trisomy 21: a 10 year retrospective review. Pediatr Surg Int. 2004;20:744–747
  22. Johannisson R, Gropp A, Winking H, Coerdt W, Rehder H, Schwinger E. Down's syndrome in the male: reproductive pathology and meiotic studies. Hum Genet. 1983;63:132–138
  23. Davisson M, Akeson E, Schmidt C, Farley J, Handel MA. Impact of trisomy on fertility and meiosis in male mice. Hum Reprod. 2007;22:468–476
  24. Pradhan M, Dalal A, Khan F, Agrawal S. Fertility in men with Down syndrome: a case report. Fertil Steril. 2006;86:1765.e1–1765.e3
  25. Arighi M, Singh A, Bosu WT, Horney FD. Histology of the normal and retained equine testis. Acta Anat (Basel). 1987;129:127–130
  26. al-Bagdadi F, Hoyt P, Karns P, Martin G, Memon M, McClure R, et al. The morphology of abdominal and inguinal cryptorchid testes in stallions: a light and electron microscopic study. Int J Fertil. 1991;36:57–64
  27. Desai SS. Down syndrome: a review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997;84:279–285

 Refereed

PII: S0737-0806(08)00203-7

doi: 10.1016/j.jevs.2008.06.003

Journal of Equine Veterinary Science
Volume 28, Issue 7 , Pages 431-436 , July 2008

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