Journal of Equine Veterinary Science
Volume 28, Issue 6 , Pages 345-350 , June 2008

Dopamine Antagonist Affects Luteal Function But Not Cyclicity During the Autumn Transition

  • S.S. King, PhD

      Affiliations

    • Department of Animal Science, Southern Illinois University, Carbondale, IL
    • ,
  • J.F. Roser, PhD

      Affiliations

    • University of California, Davis, CA
    • ,
  • D.L. Cross, PhD

      Affiliations

    • Equi-Tox Inc, Central, SC
    • ,
  • K.L. Jones, PhD

      Affiliations

    • Department of Animal Science, Southern Illinois University, Carbondale, IL

References 

  1. Nequin LG, King SS, Johnson AL, Gow GM, Ferreira-Dias GM. Prolactin may play a role in stimulating the equine ovary during the spring reproductive transition. J Equine Vet Sci. 1993;13:631–635
  2. Bennett-Wimbush K, Loch WE, Plata-Madrid J, Evans T. The effects of perphenazine and bromocriptine on follicular dynamics and endocrine profiles in anestrous pony mares. Theriogenology. 1998;49:717–733
  3. Besognet B, Hansen BS, Daels PF. Induction of reproductive function in anestrous mares using a dopamine antagonist. Theriogenology. 1997;47:467–480
  4. Brendemuehl JP, Cross DL. Influence of the dopamine antagonist domperidone on the vernal transition in seasonally anestrous mares. J Reprod Fertil. 2000;56(Suppl):185–193
  5. Scraba ST, Ginther OJ. Effects of lighting programs on onset of the ovulatory season in mares. Theriogenology. 1985;24:667–679
  6. Kooistra LH, Ginther OJ. Effect of photoperiod on reproductive activity and hair in mares. Am J Vet Res. 1975;24:1413–1419
  7. King SS, Nequin LG, Drake S, Hebner TS, Roser JF, Evans JW. Progesterone levels correlate with impending anestrus in the mare. J Equine Vet Sci. 1988;8:109–111
  8. King SS, Neumann KR, Nequin LG, Weedman BJ. Time of onset and ovarian state prior to entry into winter anestrus. J Equine Vet Sci. 1993;13:512–515
  9. Nequin LG, King SS, Roser JF, Soderstrom BL, Carnevale EM, Neumann KR. Uncoupling of the equine reproductive axes during transition into anoestrus. J Reprod Fertil. 2000;56(Suppl):153–161
  10. Johnson AL. Serum concentrations of prolactin, thyroxine and triodothyronine relative to season and the estrous cycle in the mare. J Anim Sci. 1986;62:1012–1020
  11. Fitzgerald BP, Davison LA, McManus CJ. Evidence for a seasonal variation in the ability of exogenous melatonin to suppress prolactin secretion in the mare. Dom Anim Endocrinol. 2000;18:395–408
  12. Ben-Jonathan N, Hnasko R. Dopamine as a prolactin (PRL) inhibitor. Endocrine Rev. 2001;22:724–763
  13. Melrose PA, Walker RF, Douglas RH. Dopamine in the cerebrospinal fluid of prepubertal and adult horses. Brain Behav Evol. 1990;35:98–106
  14. Thompson DL, Johnson L, St. George EI, Garza F. Concentrations of prolactin, luteinizing hormone and follicle stimulating hormone in pituitary and serum of horses: effect of sex, season and reproductive state. J Anim Sci. 1986;63:854–960
  15. Murphy BD, Rajkumar K. Prolactin as a luteotrophin. Can J Physiol Pharmacol. 1985;63:257–264
  16. Kotwica J, Skarzynski D, Bogacki M, Jaroszewski J. Role of dopamine in the secretory function of corpus luteum in cattle. J Physiol Pharmacol. 1996;47:477–486
  17. Rhodes RC, Randel RD. Effect of several biogenic amines on in vitro progesterone secretion by the bovine corpus luteum. Comp Biochem Physiol C. 1982;72:113–116
  18. King SS, Jones KL, Nequin LG, Murphy LL, Campbell AG. Evidence for a local dopamine-driven regulatory system in the mare. Theriogenology. 2002;58:619–622
  19. King SS, Campbell AG, Dille EA, Roser JF, Murphy LL, Jones KL. Dopamine receptors in equine ovarian tissues. Dom Anim Endocrinol. 2005;28:405–415
  20. King SS, Jones KL, Dille EA, Roser JF. Prolactin receptors in the corpus luteum of mares. Proceedings 15th International Congress on Animal Reproduction. 2004;[Abstr 39]
  21. Silvia WJ, Taylor ML. Relationship between uterine secretion of prostaglandin F2 alpha induced by oxytocin and endogenous concentrations of estradiol and progesterone at three stages of the bovine estrous cycle. J Anim Sci. 1989;67:2347–2353
  22. Edgerton LA, Kaminski MA, Silvia WJ. Effects of progesterone and estradiol on uterine secretion of prostaglandin F (2 alpha) in response to oxytocin in ovariectomized sows. Biol Reprod. 2000;62:365–369
  23. Roser JF, Chang Y-S, Papkoff H. Development and characterization of a homologous radioimmunoassay for equine prolactin. Proc Soc Exp Biol Med. 1984;175:510–517
  24. Irvine CHG, Alexander SL, McKinnon AO. Reproductive hormone profiles in mares during the autumn transition as determined by collection of jugular blood at 6 h intervals throughout ovulatory and anovulatory cycles. J Reprod Fertil. 2000;118:101–109
  25. Miszkiel G, Kotwica J. Mechanism of action of noradrenaline on secretion of progesterone and oxytocin by the bovine corpus luteum in vitro. Acta Vet Hung. 2001;49:39–51
  26. Johnson AL, Becker SE. Effects of physiologic and pharmacologic agents on serum prolactin concentrations in the nonpregnant mare. J Anim Sci. 1987;65:1292–1297
  27. King SS, Nequin LG. Spontaneously prolonged corpus luteum activity is a common route into anestrus in the mare. Proceedings 12th Equine Nutrition and Physiology Symposium. 1991;207–208[Abstr]
  28. Soderstrom BL, King SS, Nequin LG, Mallar ML, Hoffman L, Crawford JJ, et al. The temporal sequence of progesterone and 13,14-dihydro,15-keto PGF2α in summer and fall transitional mares. Proceedings Equine Nutrition and Physiology Symposium. 1999;202–203[Abstr]
  29. Roser JF, O'Sullivan J, Evans JW, Swedlow J, Papkoff H. Episodic release of prolactin in the cyclic mare. J Reprod Fertil. 1987;35(Suppl):687–688
  30. Homanics GE, Silvia WJ. Effects of progesterone and estradiol-17β on uterine secretion of prostaglandin F2a in response to oxytocin in ovariectomized ewes. Biol Reprod. 1988;38:804–811
  31. Edgerton LA, Kaminski MA, Silvia WJ. Effects of progesterone and estradiol on uterine secretion of prostaglandin F (2 alpha) in response to oxytocin in ovariectomized sows. Biol Reprod. 2000;62:365–369
  32. Shand N, Irvine CHG, Turner JE, Alexander SL. A detailed study of hormonal profiles in mares at luteolysis. J Reprod Fertil. 2000;56(Suppl):271–279
  33. Kucharski J, Jana B. Immuno-endocrine mechanisms connected with the creation of corpora lutea persistent in animal ovaries. Pol J Vet Sci. 2005;8:255–259
  34. Shibaya M, Murakami S, Tatsukawa Y, Skarzynski DJ, Acosta TJ. Bovine corpus luteum is an extrapituitary site of prolactin production. Mol Reprod Dev. 2006;73:512–519

 Refereed

 Reprint requests: Department of Animal Science, Food and Nutrition, MC 4417, 1205 Lincoln Drive, Southern Illinois University, Carbondale, IL 62901.

PII: S0737-0806(08)00162-7

doi: 10.1016/j.jevs.2008.04.009

Journal of Equine Veterinary Science
Volume 28, Issue 6 , Pages 345-350 , June 2008

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