Journal of Equine Veterinary Science
Volume 28, Issue 6 , Pages 370-371 , June 2008

Pergolide and Cyproheptadine: Which Medication to Choose for Treatment of Equine Cushing's Disease?

  • Thomas J. Divers, DVM, Dipl ACVIM, ACVECC

      Affiliations

    • Corresponding Author InformationReprint requests: Thomas J. Divers, DVM, Dipl ACVIM, ACVECC, Cornell University College of Veterinary Medicine, Department of Clinical Sciences, Tower Road, Ithaca, NY 14853.

References 

  1. McFarlane D. Advantages and limitations of the equine disease, pituitary pars intermedia dysfunction as a model of spontaneous dopaminergic neurodegenerative disease. Aging Res Rev. 2007;6:54–63
  2. McFarlane D. Pathogenesis and pathophysiology of equine pituitary pars intermedia dysfunction. Proceedings 25th ACVIM. 2007;197–199
  3. Donaldson MT, LaMonte BH, Morresey P, Smith G, Beech J. Treatment with pergolide or cyproheptadine of pituitary pars intermedia dysfunction (equine Cushing's disease). J Vet Intern Med. 2002;16:742–746
  4. Beech J, Boston R, Lindborg S, Russell GE. Adrenocorticotropin concentration following administration of thyrotropin-releasing hormone in healthy horses and those with pituitary pars intermedia dysfunction and pituitary gland hyperplasia. J Am Vet Med Assoc. 2007;231:417–426
  5. McGowan CM, Frost R, Pfeiffer DU, Neiger R. Serum insulin concentrations in horses with equine Cushing's syndrome: response to a cortisol inhibitor and prognostic value. Equine Vet J. 2004;36:295–298
  6. Donaldson MT, McDonnell SM, Schanbacher BJ, Lamb SV, McFarlane D, Beech J. Variation in plasma adrenocorticotropic hormone concentration and dexamethasone suppression test results with season, age, and sex in healthy ponies and horses. J Vet Intern Med. 2005;19:217–222
  7. Perkins GA, Lamb S, Erb HN, Schanbacher B, Nydam DV, Divers TJ. Plasma adrenocorticotropin (ACTH) concentrations and clinical response in horses treated for equine Cushing's disease with cyproheptadine or pergolide. Equine Vet J. 2002;34:679–685
  8. McGowan CM, Neiger R. Efficacy of trilostane for the treatment of equine Cushing's syndrome. Equine Vet J. 2003;35:414–418
  9. Harman J, Ward M. The role of nutritional therapy in the treatment of equine Cushing's syndrome and laminitis. Altern Med Rev. 2001;S4–S16

PII: S0737-0806(08)00160-3

doi: 10.1016/j.jevs.2008.04.007

Journal of Equine Veterinary Science
Volume 28, Issue 6 , Pages 370-371 , June 2008

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