Journal of Equine Veterinary Science
Volume 28, Issue 6 , Pages 367-369 , June 2008

COX Inhibitors: Making the Best Choice for the Laminitic Case

  • Thomas J. Divers, DVM, Dipl ACVIM, ACVECC

      Affiliations

    • Corresponding Author InformationReprint requests: Thomas J. Divers, DVM, Dipl ACVIM, ACVECC, Cornell University College of Veterinary Medicine, Department of Clinical Sciences, Tower Road, Ithaca, NY 14853.

References 

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  2. Burdan F, Chalas A, Szumilo J. Cyclooxygenase and prostanoids: biological implications. Postepy Hig Med Dosw. 2006;60:129–141
  3. Doucet MY, Bertone AL, Hendrickson D, Hughes F, Macallister C, McClure S, et al. Comparison of efficacy and safety of paste formulations of firocoxib and phenylbutazone in horses with naturally occurring osteoarthritis. J Am Vet Med Assoc. 2008;232:91–97
  4. Tomlinson JE, Blikslager AT. Effects of cyclooxygenase inhibitors flunixin and deracoxib on permeability of ischaemic-injured equine jejunum. Equine Vet J. 2005;37:75–80
  5. Tomlinson JE, Wilder BO, Young KM, Blikslager AT. Effects of flunixin meglumine or etodoiac treatment on mucosal recovery of equine jejunum after ischemia. Am J Vet Res. 2004;65:761–769
  6. Beretta C, Garavaglia G, Cavalli M. COX-1 and COX-2 inhibition in horse blood by phenylbutazone, flunixin, carprofen and meloxican: an in vitro analysis. Pharmacol Res. 2005;52:302–306
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  9. Brideau C, Van Staden C, Chan CC. In vitro effects of cyclooxygenase inhibitors in whole blood of horses, dogs, and cats. Am J Vet Res. 2001;62:1755–1760
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  11. Moore JN, Hardee MM, Hardee GE. Modulation of arachidonic acid metabolism in endotoxic horses: comparison of flunixin meglumine, phenylbutazone, and a selective thromboxane synthetase inhibitor. Am J Vet Res. 1996;47:110–113
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  14. Peek SF, Semrad SD, Perkins GA. Clostridial myonecrosis in horses (37 cases 1985-2000). Equine Vet J. 2003;35:86–92
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  16. Jarvis GE, Evans RJ. Platelet-activating factor and not thromboxane A2 is an important mediator of endotoxin-induced platelet aggregation in equine heparinised whole blood in vitro. Blood Coag Fibrinolysis. 1996;7:194–198
  17. Mealey KL, Matthews NS, Peck KE, Ray AC, Taylor TS. Comparative pharmacokinetics of phenylbutazone and its metabolite oxyphenbutazone in clinically normal horses and donkeys. Am J Vet Res. 1997;58:53–55
  18. Coakley M, Peck KE, Taylor TS, Matthews NS, Mealey KL. Pharmacokinetics of flunixin meglumine in donkeys, mules, and horses. Am J Vet Res. 1999;60:1441–1444
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PII: S0737-0806(08)00159-7

doi: 10.1016/j.jevs.2008.04.006

Journal of Equine Veterinary Science
Volume 28, Issue 6 , Pages 367-369 , June 2008

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