Journal of Equine Veterinary Science
Volume 28, Issue 4 , Pages 238-243 , April 2008

Adverse Effects of Zilpaterol Administration in Horses: Three Cases

  • Sarah A. Wagner, DVM, PhD

      Affiliations

    • Department of Animal and Range Sciences, North Dakota State University, Fargo, ND
    • Corresponding Author InformationReprint requests: Sarah A. Wagner, DVM, PhD, 101 Robinson Hall, North Dakota State University, Fargo, ND, 58105.
    • ,
  • Michelle S. Mostrom, DVM, PhD

      Affiliations

    • Veterinary Diagnostic Laboratory, North Dakota State University, Fargo, ND
    • ,
  • Carolyn J. Hammer, DVM, PhD

      Affiliations

    • Department of Animal and Range Sciences, North Dakota State University, Fargo, ND
    • ,
  • Jennifer F. Thorson, BS

      Affiliations

    • Department of Animal and Range Sciences, North Dakota State University, Fargo, ND
    • ,
  • David J. Smith, PhD

      Affiliations

    • Animal Metabolism-Agricultural Chemicals Research Unit, USDA ARS, Fargo, ND

References 

  1. Mersmann JH. Overview of the effects of beta-adrenergic receptor agonists on animal growth including mechanisms of action. J Anim Sci. 1998;76:160–172
  2. World Anti-Doping Agency. The 2007 Prohibited List, World Anti-Doping Code Available at: www.wada-ama.org/rtecontent/document/2007_List_En.pdf. Accessed August 17, 2007.
  3. Racing NSW. 2005 Racing NSW Annual Report Available at: www.racingnsw.com.au/pdf/2005_Annual_Report-screen.pdf. Accessed August 17, 2007.
  4. Shelver WL, Smith DJ. Tissue residues and urinary excretion of zilpaterol in sheep treated for 10 days with dietary zilpaterol. J Ag Food Chem. 2006;54:4155–4161
  5. Spangler DL. Review of the side effects associated with beta agonists. Ann Allergy. 1989;62:59–62
  6. Nazzal CA. The clinical pharmacology of clenbuterol. Southwestern Vet. 1985;36:121–125
  7. Boehringer Ingelheim Animal Health, Ventipulmin Syrup Package insert. http://www.bi-vetmedica.com/product_sites/Ventipulmin/documents/ventipulmin_rp.pdf. Accessed August 17, 2007.
  8. Skikama H. Adrenergic receptor and epinephrine-induced hyperglycemia and glucose tolerance. Am J Physiol. 1975;229:962–966
  9. Smith DJ, Turberg MP, Burnett TJ, Dalidowicz J, Thomson TD, Anderson DB. Relative safety of clenbuterol and ractopamine residues in edible tissues of hogs. Proceedings 17th International Pig Veterinary Society Congress, 2002;1:194.
  10. Lehner AF, Hughes CG, Harkins JD, Nickerson B, Mollett B, Dirikolu L, et al. Detection and confirmation of ractopamine and its metabolites in horse urine after Paylean administration. J Anal Toxicol. 2004;28:226–237
  11. Smith DJ. The pharmacokinetics, metabolism, and residues of β-adrenergic agonists in livestock. J Anim Sci. 1998;76:173–194

 Refereed

PII: S0737-0806(08)00060-9

doi: 10.1016/j.jevs.2008.02.006

Journal of Equine Veterinary Science
Volume 28, Issue 4 , Pages 238-243 , April 2008

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