Journal of Equine Veterinary Science
Volume 27, Issue 10 , Pages 446-449 , October 2007

Effect of Acute Administration of Clenbuterol on Athletic Performance in Horses

  • Guilherme C. Ferraz, PhD

      Affiliations

    • Department of Animal Morphology and Physiology, Faculty of Agricultural and Veterinary Sciences (FCAV), São Paulo State University (UNESP), Jaboticabal Campus, Jaboticabal, SP, Brazil
  • ,
  • Antonio R. Teixeira-Neto, PhD

      Affiliations

    • Department of Animal Morphology and Physiology, Faculty of Agricultural and Veterinary Sciences (FCAV), São Paulo State University (UNESP), Jaboticabal Campus, Jaboticabal, SP, Brazil
  • ,
  • Flora H.F. D'Angelis, PhD

      Affiliations

    • Department of Animal Morphology and Physiology, Faculty of Agricultural and Veterinary Sciences (FCAV), São Paulo State University (UNESP), Jaboticabal Campus, Jaboticabal, SP, Brazil
  • ,
  • José C. Lacerda-Neto, PhD

      Affiliations

    • Department of Animal Surgery and Clinical Sciences, FCAV, UNESP
  • ,
  • Antonio Queiroz-Neto

      Affiliations

    • Department of Animal Morphology and Physiology, Faculty of Agricultural and Veterinary Sciences (FCAV), São Paulo State University (UNESP), Jaboticabal Campus, Jaboticabal, SP, Brazil
    • Corresponding Author InformationReprint requests: Antonio Queiroz-Neto, Via de Acesso Prof. Paulo Donato Castellane, 14884-900, Jaboticabal, SP, Brasil.

References 

  1. Kallings P, Ingvast-Larsson C, Persson S, Appelgren LE, Forster HJ, Rominger KL. Clenbuterol plasma concentrations after repeated oral administration and its effects on cardio-respiratory and blood lactate responses to exercise in healthy Standardbred horses. J Vet Pharmacol Ther. 1991;21:243–249
  2. Robinson NE. Clenbuterol and the horse. In: Proceedings American Association of Equine Practitioners (AAEP); Lexington; 2000:229−233.
  3. Rose RJ, Evans DL. Cardiorespiratory effects of clenbuterol in fit Thoroughbred horses during a maximal exercise test. In:  Gillespie JR,  Robinson NE editor. Equine Exercise Physiology. San Diego, CA: ICEEP Publications; 1984;p. 117–131
  4. Slocombe RF, Covelli G, Bayly WM. Respiratory mechanics of horses during stepwise treadmill exercise tests, and the effect of clenbuterol pretreatment on them. Aust Vet J. 1992;69:221–225
  5. Ferraz GC, Teixeira-Neto AR, D'Angelis FHF, Lacerda-Neto JC, Queiroz-Neto A. Long-term creatine supplementation improves the aerobic capacity of horses. Cienc Rural. 2006;36:514–519
  6. Geor RJ, Hinchcliff KW, Sams RA. Beta-adrenergic blockade augments glucose utilization in horses during graded exercise. J Appl Physiol. 2000;89:1086–1098
  7. Mersmann HJ. Overview of the effects of β-adrenergic receptor agonists on animal growth including mechanisms of action. J Anim Sci. 1998;76:160–172
  8. Sleeper MM, Kearns CF, Mckeever KH. Chronic clenbuterol administration negatively alters cardiac function. Med Sci Sports Exerc. 2002;34:643–650
  9. Hochhaus G, Möllmann H. Pharmacokinetic/pharmacodynamic characteristics of the β2-agents terbutaline, salbutamol and fenoterol. Int J Clin Pharmacol Ther Toxicol. 1992;30:342–362
  10. Palermo-Neto J. Agonistas de receptores β-adrenérgicos e produção animal. In:  Spinosa HS editors. Farmacologia aplicada à medicina veterinária. Rio de Janeiro: Guanabara Koogan; 2006;p. 614–627
  11. Aarnio P, Lauritsen T, Dela F. Insulin secretion and glucose kinetics during exercise with and without pharmacological α1 and α2 receptor blockade. Diabetes. 2001;50:1834–1843
  12. Trilk JL, Lindner AJ, Greene HM, Alberghina D, Wickler SJ. A lactate-guided conditioning programme to improve endurance performance. Equine Vet J Suppl. 2002;34:122–125
  13. Geor RJ, Mccutcheon LJ, Hinchcliff KW, Sams RA. Training-induced alterations in glucose metabolism during moderate-intensity exercise. Equine Vet J Suppl. 2002;34:22–28
  14. Simões HG, Campbell CS, Kushnick MR, Nakamura A, Katsanos CSG, Baldissera V, et al. Blood glucose threshold and the metabolic responses to incremental exercise tests with and without prior lactic acidosis induction. Eur J Appl Physiol. 2003;89:603–611

 Refereed

PII: S0737-0806(07)00313-9

doi: 10.1016/j.jevs.2007.09.001

Journal of Equine Veterinary Science
Volume 27, Issue 10 , Pages 446-449 , October 2007