Journal of Equine Veterinary Science
Volume 27, Issue 4 , Pages 167-170 , April 2007

Autologous Platelet Concentrates as a Treatment of Horses with Osteoarthritis: A Preliminary Pilot Clinical Study

  • J.U. Carmona, MVZ, MSc, PhD

      Affiliations

    • From the Equine Surgery Service, Veterinary Medical Teaching Hospital, College of Veterinary Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain
    • Department of Animal Health, School of Veterinary Medicine, Universidad de Caldas, Manizales, Colombia
    • Corresponding Author InformationReprint requests: Jorge U. Carmona, MVZ, MSc, PhD, Department of Animal Health, School of Veterinary Medicine, Universidad de Caldas, Calle 65 No 26-10, Manizales, Colombia.
    • ,
  • D. Argüelles, DVM

      Affiliations

    • From the Equine Surgery Service, Veterinary Medical Teaching Hospital, College of Veterinary Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain
    • ,
  • F. Climent, DVM

      Affiliations

    • From the Equine Surgery Service, Veterinary Medical Teaching Hospital, College of Veterinary Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain
    • ,
  • M. Prades, DVM, PhD, Dip ACVS/ECVS

      Affiliations

    • From the Equine Surgery Service, Veterinary Medical Teaching Hospital, College of Veterinary Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain

References 

  1. Platt D. Articular cartilage homeostasis and the role of growth factors and cytokines in regulating matrix composition. In:  McIlwraith CW,  Trotter GW editor. Joint disease in the horse. Philadelphia: WB Saunders Company; 1996;p. 29–40
  2. Fortier LA, Nixon AJ, Mohammed HO, Lust G. Altered biological activity of equine chondrocytes cultured in a three-dimensional fibrin matrix and supplemented with transforming growth factor beta-1. Am J Vet Res. 1997;58:66–70
  3. Frisbie DD, Ghivizzani SC, Robbins PD, Evans CH, McIlwraith CW. Treatment of experimental equine osteoarthritis by in vivo delivery of the equine interleukin-1 receptor antagonist gene. Gene Ther. 2002;9:12–20
  4. Carter CA, Jolly DG, Worden CE, Hendren DG, Kane CJ. Platelet-rich plasma gel promotes differentiation and regeneration during equine wound healing. Exp Mol Pathol. 2003;74:244–255
  5. Sutter WW, Kaneps AJ, Bertone AL. Comparison of hematologic values and transforming growth factor-β and insulin-like growth factor concentrations in platelet concentrates obtained by use of buffy coat and apheresis methods from equine blood. Am J Vet Res. 2004;65:924–930
  6. Anitua E, Andia I, Ardanza B, Nurden P, Nurden AT. Autologous platelets as a source of proteins for healing and tissue regeneration. Thromb Haemost. 2004;91:4–15
  7. Anonymous. Guide for veterinary service and judging of equestrian events: definition and classification of lameness. Lexington, KY: American Association of Equine Practitioners (AAEP); 1991;
  8. Argüelles D, Carmona JU, Pastor J, Iborra A, Viñals L, Martínez P, et al. Evaluation of single and double centrifugation tube method for concentrating equine platelets. Res Vet Sci. 2006;81:237–245
  9. Van Miert ASJ. Present concepts on the inflammatory modulators with special reference to cytokines. Vet Res Commun. 2002;26:111–126
  10. Caron JP. Osteoartritis. In:  Ross MW,  Dyson SJ editor. Diagnosis and management of lameness in the horse. Philadelphia: Saunders; 2003;p. 572–591

 Refereed

PII: S0737-0806(07)00084-6

doi: 10.1016/j.jevs.2007.02.007

Journal of Equine Veterinary Science
Volume 27, Issue 4 , Pages 167-170 , April 2007

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