Journal of Equine Veterinary Science
Volume 26, Issue 11 , Pages 517-528 , November 2006

Estradiol interactions with dopamine antagonists in mares: Prolactin secretion and reproductive traits

  • K.K. Kelley, MS

      Affiliations

    • Department of Animal Sciences, Louisiana Agricultural Experiment Station, Louisiana State University Agricultural Center, Baton Rouge, LA
    • ,
  • D.L. Thompson Jr, PhD

      Affiliations

    • Department of Animal Sciences, Louisiana Agricultural Experiment Station, Louisiana State University Agricultural Center, Baton Rouge, LA
    • Corresponding Author InformationReprint requests: D.L. Thompson, Jr., Department of Animal Sciences, Louisiana Agricultural Experiment Station, Louisiana State University Agricultural Center, S. Campus Drive, Francioni Hall, Baton Rouge, LA 70803
    • ,
  • W.A. Storer, MS

      Affiliations

    • Department of Animal Sciences, Louisiana Agricultural Experiment Station, Louisiana State University Agricultural Center, Baton Rouge, LA
    • ,
  • P.B. Mitcham, BS

      Affiliations

    • Department of Animal Sciences, Louisiana Agricultural Experiment Station, Louisiana State University Agricultural Center, Baton Rouge, LA
    • ,
  • R.M. Gilley, BS

      Affiliations

    • BioRelease Technologies, Birmingham, AL
    • ,
  • P.J. Burns, PhD

      Affiliations

    • BioRelease Technologies, Birmingham, AL
    • Burns BioSolutions, Lexington, KY

References 

  1. Nequin LG , King SS , Johnson AL , Gow GM , Ferreira Dias GM . Prolactin may play a role in stimulating the equine ovary during the spring transition . J Equine Vet Sci . 1993;13:631–635
  2. Thompson DL , Hoffman R , DePew CL . Prolactin administration to seasonally anestrous mares: Reproductive, metabolic, and hair shedding responses . J Anim Sci . 1997;75:1092–1099
  3. Brendemuehl JP , Cross DL . Influence of the dopamine antagonist domperidone on the vernal transition in seasonally anoestrous mares . J Reprod Fertil (Suppl) . 2000;56:185–193
  4. Besognet B , Hansen BS , Daels PF . Induction of reproductive function in anestrous mares using a dopamine antagonist . Theriogenology . 1997;47:467–480
  5. Donadeu FX , Thompson DL . Administration of sulpiride to anovulatory mares in winter: Effects on prolactin and gonadotropin concentrations, ovarian activity, ovulation and hair shedding . Theriogenology . 2002;57:963–976
  6. Thompson DL , DePew CL . Prolactin, gonadotropin, and hair shedding responses to daily sulpiride administration in geldings in winter . J Anim Sci . 1997;75:1087–1091
  7. Thompson DL , Garza F , St George RL , Rabb MH , Barry BE , French DD . Relationships among LH, FSH and prolactin secretion, storage and response to secretagogue and hypothalamic GnRH content in ovariectomized pony mares administered testosterone, dihydrotestosterone, estradiol, progesterone, dexamethasone or follicular fluid . Domest Anim Endocrinol . 1991;8:189–199
  8. Garcia MC , Ginther OJ . Regulation of plasma LH by estradiol and progesterone in ovariectomized mares . Biol Reprod . 1978;19:447–453
  9. Henneke DR , Potter GD , Kreider JL , Yeates BF . Relationship between condition score, physical measurements and body fat percentage in mares . Equine Vet J . 1983;15:371–372
  10. Colborn DR , Thompson DL , Rahmanian MS , Roth TL . Plasma concentrations of cortisol, prolactin, luteinizing hormone, and follicle stimulating hormone in stallions after physical exercise and injection of secretagogue before and after sulpiride treatment in winter . J Anim Sci . 1991;69:3724–3732
  11. Thompson DL , Godke RA , Squires EL . Testosterone effects on mares during synchronization with altrenogest: FSH, LH, estrous duration and pregnancy rate . J Anim Sci . 1983;56:678–686
  12. Steel RGD , Torrie JH , Dickey DA . Principles and Procedures of Statistics: A Biometrical Approach . 3rd Ed.. New York: McGraw-Hill; 1997;
  13. del Pozo E , Brownell J . Prolactin. I: mechanisms of control, peripheral actions and modification by drugs . Horm Res . 1979;10:143–174
  14. Ryan R , Shupnik MA , Gorski J . Effect of estrogen on preprolactin messenger ribonucleic acid sequences . Biochemistry . 1979;18:2044–2048
  15. Lieberman ME , Maurer RA , Claude P , Gorski J . Prolactin synthesis in primary cultures of pituitary cells: regulation by estradiol . Mol Cell Endocrinol . 1982;25:277–294
  16. Gershengorn MC , Marcus Samuels BE , Geras E . Estrogens increase the number of thyrotropin releasing hormone receptors on mammotropic cells in culture . Endocrinology . 1979;105:171–176
  17. Advis JP , White SS , Ojeda SR . Delayed puberty induced by chronic suppression of prolactin release in the female rat . Endocrinology . 1981;109:1321–1330
  18. Chowdhury M , Kabir SN , Pal AK , Pakrashi A . Modulation of luteinizing hormone receptors: Effect of an inhibitor of prolactin secretion, p-coumaric acid . J Endocrinol . 1983;98:307–311
  19. Hussein MO , Zipf WB . Temporal relationship of the prolactin-dependent LH-induced LH receptor to the LH stimulus . J Cell Physiol . 1988;134:137–142
  20. Bour B, Palmer E. Stimulation of seasonally anovulatory pony mares with repeated low doses of hCG. In: Proceedings of the 10th International Congress on Animal Reproduction and Artificial Insemination; 1984:Abstr 310.
  21. Champion MC , Hartnett M , Yen M . Domperidone, a new dopamine antagonist . CMAJ . 1986;135:457–461
  22. Johnson AL . Serum concentrations of prolactin, thyroxine and triiodothyronine relative to season and the estrous cycle in the mare . J Anim Sci . 1986;62:1012–1020
  23. Thompson DL , Pickett BW , Squires EL , Nett TM . Effect of testosterone and estradiol 17β alone and in combination on LH and FSH concentrations in pituitary and blood serum of geldings and in serum after GnRH . Biol Reprod . 1979;21:1231–1237
  24. Garza F , Thompson DL , St George RL , French DD . Androgen and estradiol effects on gonadotropin secretion and response to GnRH in ovariectomized pony mares . J Anim Sci . 1986;62:1654–1659
  25. Woodley SL , Burns PJ , Douglas RH , Oxender WD . Prolonged interovulatory interval after oestradiol treatment in mares . J Reprod Fertil . 1979;27(Suppl):205–209
  26. Thompson DL . Effects of estradiol 17β and testosterone on semen, sexual behavior and gonadotropins in geldings. PhD Dissertation . Fort Collins: Colorado State University; 1978;

 RefereedApproved for publication by the Director of the Louisiana Agric. Exp. Stn. as manuscript No. 06 18 0228. We thank A.F. Parlow and the Natl. Inst. of Diabetes and Digestive and Kidney Diseases, National Hormone and Pituitary Program, Harbor University of California Los Angeles Medical Center, Torrance, CA, for reagents.

PII: S0737-0806(06)00499-0

doi: 10.1016/j.jevs.2006.09.008

Journal of Equine Veterinary Science
Volume 26, Issue 11 , Pages 517-528 , November 2006

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