Journal of Equine Veterinary Science
Volume 26, Issue 6 , Pages 271-274 , June 2006

Insulin resistance demonstrated by a specific quantitative method in a hyperlipemic laminitic pony

  • Tanja M. Hess, DVM, MS, PhD

      Affiliations

    • Departments of Large Animal Clinical Sciences and Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA
    • Marion DuPont Equine Medical Center, Leesburg, VA
    • Middleburg Agricultural Research and Extension Center, Middleburg, VA
    • ,
  • Kimberley H. Treiber, MS

      Affiliations

    • Departments of Large Animal Clinical Sciences and Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA
    • Marion DuPont Equine Medical Center, Leesburg, VA
    • Middleburg Agricultural Research and Extension Center, Middleburg, VA
    • ,
  • David S. Kronfeld, PhD, DSc, MVSc, MACVSc, DACVIM, DACVN

      Affiliations

    • Corresponding Author InformationReprint requests: D. S. Kronfeld, 447 New Zion Road, Pembroke, VA 24136
    • Departments of Large Animal Clinical Sciences and Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA
    • Marion DuPont Equine Medical Center, Leesburg, VA
    • Middleburg Agricultural Research and Extension Center, Middleburg, VA
    • ,
  • Martin O. Furr, DVM, PhD, DACVIM

      Affiliations

    • Departments of Large Animal Clinical Sciences and Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA
    • Marion DuPont Equine Medical Center, Leesburg, VA
    • Middleburg Agricultural Research and Extension Center, Middleburg, VA

References 

  1. Jeffcott LB , Field JR . Current concepts of hyperlipaemia in horses and ponies . Vet Rec . 1985;116:461–466
  2. Jeffcott LB , Field JR , McLean JG , O'Dea K . Glucose tolerance and insulin sensitivity in ponies and Standardbred horses . Equine Vet J . 1986;18:97–101
  3. Kronfeld DS , Treiber KH , Geor RV . Comparison of nonspecific indications and quantitative methods for the assessment of insulin resistance in horses and ponies . J Am Vet Med Assoc . 2005;225:712–719
  4. Bergman RN , Ider YZ , Bowden CR , Cobelli C . Quantitative estimation of insulin sensitivity . Am J Physiol . 1979;236:E667–E677
  5. Boston RC , Stefanovski D , Moate PJ , Sumner AE , Watanabe RM , Bergman RN . MINMOD Millenium: a computer program to calculate glucose effectiveness and insulin sensitivity from the frequently sampled intravenous glucose tolerance test . Diabetes Technol Ther . 2003;5:1003–1015
  6. Hoffman RM , Boston RC , Stefanovski D , Kronfeld DS , Harris PA . Obesity and diet affect glucose dynamics and insulin sensitivity in Thoroughbred geldings . J Anim Sci . 2003;81:2333–2342
  7. Treiber KH , Kronfeld DS , Boston RC , Staniar WB , Harris PA . Insulin resistance and compensation in Thoroughbred weanlings adapted to high-glycemic meals . J Anim Sci . 2005;83:2357–2364
  8. Rijnen KEPM , van der Kolk JH . Determination of reference range values indicative of glucose metabolism and insulin resistance by use of glucose clamp techniques in horses and ponies . Am J Vet Res . 2003;64:1260–1264
  9. Treiber KH , Kronfeld DS , Hess TM , Boston RC , Harris PA . Use of proxies and reference quintiles obtained from minimal model analysis for determination of insulin sensitivity and pancreatic beta-cell responsiveness in horses . Am J Vet Res . 2005;66:2114–2121
  10. Kahn SE . The importance of β-cell failure in the development and progression of type 2 diabetes . J Clin Endocrin Metab . 2001;86:4047–4058
  11. Tasker JB , Whiteman CE , Martin BR . Diabetes mellitus in the horse . J Am Vet Med Assoc . 1966;149:393–399
  12. Baker JR , Ritchie HE . Diabetes mellitus in the horse: a case report and review of the literature . Equine Vet J . 1974;6:7–11
  13. Muylle E , van den Hende C , Deprez P , Nuytten J , Oyaert W . Non-insulin dependent diabtetes mellitus in a horse . Equine Vet J . 1986;18:145–146
  14. Saltiel AR , Kahn CR . Insulin signaling and the regulation of glucose and lipid metabolism . Nature . 2001;414:799–806
  15. Boden G . Role of fatty acids in the pathogenesis of insulin resistance and NIDDM . Diabetes . 1996;45:3–10
  16. Johnson PJ . The equine metabolic syndrome: peripheral Cushing's syndrome . Vet Clin Equine . 2002;18:272–293
  17. Politt CC , Kyaw-Tanner M , French KT , van Eps A , Hendrikz JK , Daradka M . Equine laminitis . Proc 49th Ann Conv Amer Assoc Equine Pract . 2003;21–25
  18. Treiber KH , Kronfeld DS , Hess TM , Byrd BM , Splan RK , Staniar WB . Evaluation of genetic and metabolic predispositions and nutritional risk factors for pasture-associated laminitis in ponies . J Am Vet Med Assoc . 2006;228:1538–1545
  19. Treiber KH, Kronfeld DS, Geor RJ. Insulin resistance in equids—likely roles in laminitis. J Nutr (in press).
  20. Pratt S , Geor R , McCutcheon J , et al.   Repeatability of two methods for the assessment of glucose metabolism and insulin sensitivity in horses (abstract) . J Vet Int Med . 2003;17:455
  21. Storlien LH , Higgins JA , Thomas TC , Brown MA , Wang HQ , Huang XF , et al.   Diet composition and insulin action in animal models . Br J Nutr . 2000;83(Suppl 1):S85–S90
  22. Neeley KA , Herthel DJ . Essential fatty acid supplementation as a preventative for carbohydrate overload-induced laminitis . Proc Am Assoc Equine Pract . 1997;43:367–369
  23. Rivellese AA , Lilli S . Quality of dietary fatty acids, insulin sensitivity, and type 2 diabetes . Biomed Pharmacother . 2003;57:84–87
  24. Williams CA , Kronfeld DS , Staniar WB , Harris PA . Plasma glucose and insulin responses of Thoroughbred mares fed a meal high in starch and sugar or fat and fiber . J Anim Sci . 2001;79:2196–2201
  25. Kronfeld DS , Harris PA . Equine grain-associated disorders (EGAD) . Compend Contin Educ Vet Pract . 2003;25:974–982
  26. Kronfeld DS , Rodiek AV , Stull CL . Glycemic index, glycemic load, and glycemic dietetics . J Equine Vet Sci . 2004;24:399–404
  27. Kronfeld DS, Treiber KH, Hess TM, Splan RK, Byrd BM, Staniar WB, White NA. Metabolic syndrome in healthy ponies facilitates nutritional countermeasures against pasture laminitis. J Nutr (in press).

PII: S0737-0806(06)00236-X

doi: 10.1016/j.jevs.2006.04.009

Journal of Equine Veterinary Science
Volume 26, Issue 6 , Pages 271-274 , June 2006

Article Tools